Psilocybin, which is produced by many species of mushrooms, is a naturally occurring psychedelic compounda group of substances that change or enhance sensory perceptions, thought processes, and energy levels which has shown substantial effects for managing anxiety and depression among people with cancer.

Psilocybin at a glance

Psilocybin is a naturally occurring psychedelic compound produced by many species of mushrooms, which are commonly called “magic mushrooms.” As a controlled substance in many countries, psilocybin can be obtained legally only in a few countries and some individual states or cities. It has one of the highest safety profiles among psychedelic substances, although medical supervision during use is advised. 

Psilocybin has been studied for managing anxiety and depression among people with cancer, especially end-of-life anxiety. It shows substantial and lasting benefits from a single dose. Legal access currently is mainly through clinical trials, although Oregon has a system for legalized, supervised use.

CancerChoices ratings for psilocybin

We rate psilocybin on seven attributes, with 0 the lowest rating and 5 the highest. We rate the strength of the evidence supporting the use of psilocybin for a medical benefit, such as improving treatment outcomes or managing side effects.

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0

Improving treatment outcomes

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Optimizing your body terrain

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Managing side effects and promoting wellness

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Reducing cancer risk

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Use by integrative oncology experts

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Safety

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Affordability and access

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Author

Nancy Hepp, MS

Lead Researcher
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Ms. Hepp is a researcher and communicator who has been writing and editing educational content on varied health topics for more than 20 years. She serves as lead researcher and writer for CancerChoices and also served as the first program manager. Her graduate work in research and cognitive psychology, her master’s degree in instructional design, and her certificate in web design have all guided her in writing and presenting information for a wide variety of audiences and uses. Nancy’s service as faculty development coordinator in the Department of Family Medicine at Wright State University also provided experience in medical research, plus insights into medical education and medical care from the professional’s perspective.

Nancy Hepp, MS Lead Researcher

Reviewers

Laura Pole, MSN, RN, OCNS

Senior Clinical Consultant
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Laura Pole is senior clinical consultant for CancerChoices. Laura is an oncology clinical nurse specialist who has been providing integrative oncology clinical care, navigation, consultation, and education services for over 40 years. She is the co-creator and co-coordinator of the Integrative Oncology Navigation Training at Smith Center for Healing and the Arts in Washington, DC. Laura also manages the “Media Watch Cancer News That You Can Use” listserv for Smith Center/Commonweal. In her role as a palliative care educator and consultant, Laura has served as statewide Respecting Choices Faculty for the Virginia POST (Physician Orders for Scope of Treatment) Collaborative as well as provided statewide professional education on palliative and end-of-life care for the Virginia Association for Hospices and Palliative Care.

For CancerChoices, Laura curates content and research, networks with clinical and organizational partners, brings awareness and education of integrative oncology at professional and patient conferences and programs, and translates research into information relevant to the patient experience as well as clinical practice.

Laura sees her work with CancerChoices as a perfect alignment of all her passions, knowledge and skills in integrative oncology care. She is honored to serve you.

Laura Pole, MSN, RN, OCNS Senior Clinical Consultant

Jennifer Bires, LICSW, OSW-C was recently the executive director of the Smith Center for Healing and the Arts in Washington, DC. She is a rising star in the psycho-oncology field with almost a decade of experience as an oncology social worker, most recently at George Washington University in DC where she helped create the cancer support program. During her tenure at GWU she created a number of deep and impactful programs for families, young adults, and patients and helped to ensure program success by defining and tracking outcomes. Jennifer received the 2017 Oncology Social Worker of The Year Award from the Association of Oncology Social Workers.

Jennifer Bires, LICSW, OSW-C CancerChoices Advisor

Last update: December 2, 2024

Last full literature review: July 2024

CancerChoices provides information about integrative in cancer care, a patient-centered approach combining the best of conventional care, self care and evidence-informed complementary care in an integrated plan cancer care. We review complementaryin cancer care, complementary care involves the use of therapies intended to enhance or add to standard conventional treatments; examples include supplements, mind-body approaches such as yoga or psychosocial therapy, and acupuncture therapies and self-care lifestyle actions and behaviors that may impact cancer outcomes; examples include eating health-promoting foods, limiting alcohol, increasing physical activity, and managing stress practices to help patients and professionals explore and integrate the best combination of conventionalthe cancer care offered by conventionally trained physicians and most hospitals; examples are chemotherapy, surgery, and radiotherapy and complementary therapies and practices for each person.

Our staff have no financial conflicts of interest to declare. We receive no funds from any manufacturers or retailers gaining financial profit by promoting or discouraging therapies mentioned on this site.

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