Reducing your risk of breast cancer

If you don’t have a cancer diagnosis, you may want to know what you can do to reduce your risk of developing breast cancer. Perhaps you have a family member with breast cancer, or you’ve been told you’re in a high-risk group.

Top practices and therapies we have reviewed for reducing your risk of cancer

These practices and therapies have at least modest evidence for reducing your risk of cancer or of breast cancer specifically. We add to this list as we complete new reviews of practices and therapies.

On this page

Risk factors for breast cancer

Breast cancer risk factors help shape conditions that foster higher risk of breast cancer and less favorable outcomes.

Generally accepted individual risk factors for breast cancer include these, with varying levels of association:1Schettler T. The Ecology of Breast Cancer: The Promise of Prevention and the Hope for Healing. Science and Environmental Health Network and The Collaborative on Health and the Environment. October 2013; Sun YS, Zhao Z et al. Risk factors and preventions of breast cancer. International Journal of Biological Sciences. 2017 Nov 1;13(11):1387-1397; Rice MS, Eliassen AH et al. Breast cancer research in the Nurses’ Health Studies: exposures across the life course. American Journal of Public Health. 2016 Sep;106(9):1592-8; Breast Cancer Risk Factors. Breast Cancer Prevention Partners. Viewed May 23, 2023.

Genetic factors and family history of breast cancer

Pregnancy history (late-age first pregnancy or no pregnancies)

Menstrual history (early age of puberty or later age of menopause)

Dense breast tissue

Chest radiation

Recent oral contraceptive use—increased risk may disappear within a few years after use is discontinued;2ASCO Post Staff. Study clarifies time-dependent effects of oral contraceptives on risk of ovarian, endometrial, and breast cancers. ASCO Post. December 23, 2020. Viewed January 5, 2021; Karlsson T, Johansson T, Höglund J, Ek WE, Johansson Å. Time-dependent effects of oral contraceptive use on breast, ovarian and endometrial cancers. Cancer Research. 2020 Dec 17:canres.2476.2020. increased risk has been found from use of a levonorgestrel-releasing intrauterine device (IUD)3Yi H, Zhang N et al. Association of levonorgestrel-releasing intrauterine device with gynecologic and breast cancers: a national cohort study in Sweden. American Jouranl of Obstetrics and Gynecology. 2024 Oct;231(4):450.e1-450.e12; Zürcher A, Knabben L, Janka H, Stute P. Influence of the levonorgestrel-releasing intrauterine system on the risk of breast cancer: a systematic review. Archives of Gynecology and Obstetrics. 2023 Jun;307(6):1747-1761.

Combination hormone replacement therapy (see below)

Cigarette smoking

Alcohol consumption

Further risk factors for which the strength of evidence varies from strong to probable to plausible, from Dr. Ted Schettler’s The Ecology of Breast Cancer4Schettler T. The Ecology of Breast Cancer: The Promise of Prevention and the Hope for Healing. Science and Environmental Health Network and The Collaborative on Health and the Environment. October 2013. and other sources as noted:

Certain kinds of diets (see Eating Well below)

Inadequate physical activity5Al Ajmi K, Lophatananon A, Mekli K, Ollier W, Muir KR. Association of nongenetic factors with breast cancer risk in genetically predisposed groups of women in the UK Biobank Cohort. JAMA Network Open. 2020;3(4):e203760.

Exposures to certain environmental chemicals or contaminants, such as some hair products6Eberle CE, Sandler DP, Taylor KW, White AJ. Hair dye and chemical straightener use and breast cancer risk in a large US population of black and white women. International Journal of Cancer. 2019 Dec 3.

Body fat: even among people considered of normal weight and not overweight (BMI less than 25), increased body fat is associated with increased risk of postmenopausal breast cancer.7Arthur RS, Dannenberg AJ, Kim M, Rohan TE. The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank. British Journal of Cancer. 2021 Mar 15. Higher body mass index (BMI) is also linked to higher risk of second primary cancers among breast cancer survivors.8Feigelson HS, Bodelon C, Powers JD et al. Body mass index and risk of second cancer among women with breast cancer. Journal of the National Cancer Institute. 2021 Apr 5:djab053.

Ionizing radiation

Non-ionizing radiation

Inadequate vitamin D status

Shift work

Ambient light at night

Stress

Severe life events, anxiety, depression, perception of insufficient social support, or avoiding coping strategy9Kruk J, Aboul-Enein BH, Bernstein J, Gronostaj M. Psychological stress and cellular aging in cancer: a meta-analysis. Oxidative Medicine and Cellular Longevity. 2019 Nov 13;2019:1270397.

Societal contributors to these factors, such as poverty, violence, racism, or other marginalization

Race

Infertility

Infertility is possibly linked to male invasive breast cancer but not in situ, although the reason for the connection is unknown.10Swerdlow AJ, Bruce C, Cooke R, Coulson P, Jones ME. Infertility and risk of breast cancer in men: a national case-control study in England and Wales. Breast Cancer Research. 2022 May 17;24(1):29.

Medical treatments

Some medical treatments are linked to higher risk of breast cancer.

H2 blockers

Radiotherapy, x-rays, and other medical imaging

Hormone replacement therapy and breast cancer risk

All types of menopausal hormone replacement therapy using estrogen only or combined estrogen and progestogen—except vaginally inserted estrogen—are linked to an increased risk of breast cancer.11Collaborative Group on Hormonal Factors in Breast Cancer. Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence. Lancet. 2019 Aug 29. pii: S0140-6736(19)31709-X. Estrogen-only therapy and estrogen-progestogen therapy containing micronized progesterone or dydrogesterone are associated with lower breast cancer risk compared to other combined hormone therapy regimens.12Rozenberg S, Di Pietrantonio V, Vandromme J, Gilles C. Menopausal hormone therapy and breast cancer risk. Best Practice & Research. Clinical Endocrinology & Metabolism. 2021 Dec;35(6):101577.

Use of menopausal hormone therapy for 10 years results in about twice as much excess breast cancer risk compared to five years of use, but there appears to be little risk from use of menopausal hormone therapy for less than one year, or from topical use of vaginal estrogens that are applied locally as creams or pessaries and are not intended to reach the bloodstream.13Nelson R. Menopausal hormone therapy and breast cancer link confirmed. Medscape. August 29, 2019. Viewed September 24, 2019. Among women genetically predisposed to breast cancer, use of hormone replacement therapy for more than five years is associated with greater cancer risk.14Al Ajmi K, Lophatananon A, Mekli K, Ollier W, Muir KR. Association of nongenetic factors with breast cancer risk in genetically predisposed groups of women in the UK Biobank Cohort. JAMA Network Open. 2020;3(4):e203760.

Helpful links on hormone therapy and breast cancer risk

Breast cancer and cardiovascular disease

People who are diagnosed with cardiovascular disease are less likely to be diagnosed with breast cancer.15Bell CF, Lei X et al. Risk of cancer after diagnosis of cardiovascular disease. Journal of the American College of Cardiology: CardioOncology. Apr 11, 2023. This may be due to the opposite effects of estrogen on these two diseases.

Self-care practices and complementary therapies for reducing your risk of breast cancer

Self-care practices are the foundation of risk reduction, and some complementary therapies may also reduce risk. Please also review the Safety and precautions page within the linked reviews for guidance on safe use. We recommend supervision from a medical professional trained in the use of complementary therapies. 

Details of the evidence supporting the statements are available through the image links.

Strong, good, or modest evidence of benefit for reducing cancer risk

Strong evidenceconsistent, significant effects in several large (or at least one very large) well designed clinical studies or at least two meta-analyses of clinical studies of moderate or better quality (or one large meta-analysis) finding similar results (this is the CancerChoices definition; other researchers and studies may define this differently) indicates confidence that the practice or therapy has an effect as noted. Good evidencesignificant effects in one large or several mid-sized and well-designed clinical studies (randomized controlled trials (RCTs) with an appropriate placebo or other strong comparison control or observational studies that control for confounds) (this is the CancerChoices definition; other researchers and studies may define this differently) indicates that the practice or therapy is linked to the outcomes described with reasonable certainty. Modest evidencesignificant effects in at least three small but well-designed randomized controlled trials (RCTs), or one or more well-designed, mid-sized clinical studies of reasonably good quality (RCTs or observational studies), or several small studies aggregated into a meta-analysis (this is the CancerChoices definition; other researchers and studies may define this differently) means the practice or therapy may be linked to the outcomes described, but with a lower degree of certainty.

The evidence for these effects is described in the reviews available through the image links.

Healthy lifestyle: modest evidence

Breast cancer risk:

  • Lower risk of breast cancer among people with higher adherence to World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations regarding diet, physical activity, and body weight (modest evidence)
Eating Well: strong to modest evidence

Some foods and eating patterns are linked to lower risk of cancer, while others are linked to a higher risk. Find strategies for eating well in this handbook.

Breast cancer risk:

  • Moderately lower risk of breast cancer among Asian people eating a healthy dietary pattern or adhering to a healthy eating index, and 44% higher risk of breast cancer among people eating an unhealthy diet pattern (modest evidence)
  • Moderately lower risk of breast cancer among people eating more vegetables, especially cruciferous vegetables (broccoli family) or carrots (modest evidence)
  • Moderately lower risk of breast cancer among people eating fruits and vegetables (modest evidence)
  • Moderately lower risk of breast cancer among people eating fruits and vegetables (modest evidence)
  • Moderately lower risk of breast cancer among Asian people eating soy protein but no evidence of an effect from soy foods as a whole (modest evidence)
  • Moderately lower risk of breast cancer among people eating mushrooms (good evidence)
  • Lower risk of breast cancer among postmenopausal women eating foods high in lignans—flaxseed and sesame, but also whole grains, berries and some other fruits, vegetables such as broccoli and kale, and green tea—or fiber (good evidence)
  • Lower risk of breast cancer among people eating the highest levels of olive oil (good evidence)
  • Moderately lower risk of breast cancer among people eating mushrooms (good evidence)
  • Lower risk of breast cancer among postmenopausal women eating foods high in lignans—flaxseed and sesame, but also whole grains, berries and some other fruits, vegetables such as broccoli and kale, and green tea—or fiber (good evidence)
  • Slightly higher risk of breast cancer among people eating red or processed meat, and increasing risk with higher consumption (good evidence)
  • Little evidence of any impact for most breast cancer types among women eating higher levels of fat, dairy foods or calcium, but an increased risk of ER-negative tumors with higher levels of yogurt (good evidence)
  • Higher risk of breast cancer among people eating higher levels of ultra-processed foods such as pastries, sweet or salty snacks, breakfast cereal, sweetened drinks, sweetened yogurt, hot dogs or meat nuggets, sausages, and other highly processed foods (good evidence)
  • Slightly higher risk of breast cancer among people eating 5 or more eggs per week (modest evidence)

Risk of cancer as a whole:

  • Lower risk of cancer among people eating fermented dairy foods (yogurt, kefir, cultured cheese)
  • Lower cancer risk among people following anti-inflammatory diets compared to pro-inflammatory diets (good evidence)
  • Lower risk of cancer as a whole among people eating the highest levels of olive oil (good evidence)
  • Moderately lower risk of cancer as a whole among people eating mushrooms (modest evidence)
  • Higher risk of cancer as a whole among people drinking higher levels of sugar-sweetened beverages (modest evidence)
  • Higher risk of cancer as a whole among people eating higher levels of ultra-processed foods such as pastries, sweet or salty snacks, breakfast cereal, sweetened drinks, sweetened yogurt, hot dogs or meat nuggets, sausages, and other highly processed foods (good evidence)

Cancer mortality among people without cancer at the start of a study:

  • Lower cancer mortality among people regularly eating chili peppers (strong evidence)
  • Lower cancer mortality among people following a diet high in vegetables—but not starchy vegetables—and fruits before diagnosis (good evidence)
  • Lower cancer mortality among people drinking several cups of coffee per day (good evidence)
  • Higher cancer mortality among people eating higher levels of saturated fats (good evidence)
Moving More: strong to good evidence

Find strategies for moving more in this handbook.

Breast cancer risk:

  • A slightly lower risk of a breast cancer diagnosis among people participating in more physical activity (strong evidence)
  • Higher risk of breast cancer among people with more sitting time (strong evidence)

Breast cancer mortality among people without cancer at the start of a study:

  • Lower breast cancer mortality among people without cancer at baseline participating in higher levels of physical activity (good evidence)

Risk of cancer as a whole:

  • A lower risk of a cancer diagnosis among people with higher levels of physical activity (strong evidence)

Cancer mortality among people without cancer at the start of a study:

  • Lower cancer mortality among people without cancer at baseline and who had the highest levels of physical activity (strong evidence)

Recommended in at least one clinical practice guideline; see guidelines below

Combining Eating Well and Moving More: modest evidence

Breast cancer risk:

  • Better balances of breast cancer-related sex hormones among people combining diet and exercise (modest evidence)
Managing Stress: strong to weak evidence

Find approaches for managing stress in this handbook.

Breast cancer risk:

  • A slightly lower risk of breast cancer among people with less stress (weak and conflicting evidence)

Risk of cancer as a whole:

  • Lower risk of cancer as a whole among people with better stress-management skills (good evidence)
Sleeping Well: mixed evidence

Find approaches to promote better sleep in these handbooks.

Breast cancer risk:

  • Lower risk of breast cancer with long sleep duration (9 hours or more) (good evidence)
  • No evidence of an effect on risk of breast cancer among people with short sleep duration (less than 6 hours) in a combined analysis of studies
  • Insufficient (conflicting) evidence of any effect of night work on risk of breast cancer

Cancer mortality among people without cancer at the start of a study:

  • Slightly to moderately higher cancer mortality among people with long sleep durations (good evidence)
  • Slightly higher cancer mortality among people without cancer at baseline with sleep durations of 6 hours or less (preliminary (conflicting) evidence)
  • No evidence of higher cancer mortality among people with insomnia symptoms or who take daytime naps in combined analyses of studies
Creating a Healing Environment: mixed evidence

Many environmental exposures are linked to a higher risk of cancer, while a few are linked to a lower risk. Find approaches for creating a more healing environment in this handbook.

Breast cancer risk:

  • Higher breast cancer incidence among people living in areas with poorer environmental quality (modest evidence)
  • Higher risk of female breast cancer among people exposed to x-rays or ionizing radiation from other medical imaging (strong evidence)
  • Higher risk of breast cancer among people living in areas with higher air pollution levels (good evidence)
  • Lower risk of breast cancer among people getting sun exposure (modest evidence)
  • Substantially higher risk of breast cancer among people exposed to some pesticides (modest evidence)
  • Higher risk of breast cancer among people with occupational exposures to PAHs (modest evidence)
  • Slightly increased risk of breast cancer among people using permanent hair dye 
  • Higher risk of breast cancer among women with higher body levels of heavy metals (preliminary evidence)
  • Higher risk of breast cancer among women with higher body levels of phthalates or PCBs (preliminary evidence)
  • Slightly higher risk of breast cancer among people applying semi-permanent dye to others non-professionally (preliminary evidence)
  • Higher risk of breast cancer among women with a sister with breast cancer and using hair straightener or applying it to others non-professionally (weak evidence)
  • Insufficient (conflicting) evidence of any higher risk of breast cancer among people working at night

Risk of cancer as a whole:

  • Higher risk of cancer as a whole among people exposed to dioxin (TCDD) (strong evidence)
  • Higher risk of cancer, including secondary cancer, among people receiving radiation therapy  (strong evidence)
  • Higher risk of cancer as a whole among people exposed to wood dust (strong evidence)
  • Slightly higher risk of solid cancers among adults exposed to low cumulative doses  of ionizing radiation (modest evidence)
  • Slightly higher risk of cancer as a whole among people living in urban areas characterized by higher concentrations of polycyclic aromatic hydrocarbons (PAHs) (modest evidence)
  • Higher risk of childhood cancer among children exposed to PAHs from playgrounds surfaced with poured rubber (preliminary evidence)
  • Slightly lower risk of cancer and cancer-related death as a whole among people ever using hair dye (weak evidence)
  • Insufficient (conflicting) evidence of lower risk of cancer among adults eating organic foods 
  • No evidence of an effect on risk of solid cancers other than melanoma and other skin cancer among people using indoor tanning devices

Cancer mortality among people without cancer at the start of a study:

  • Slightly higher risk of cancer mortality among people without cancer at baseline working at night (good evidence)
  • Small increases in mortality from cancer as a whole among people without cancer at baseline with higher exposures to particulate air pollutants(modest evidence)
Sharing Love and Support: mixed evidence

Find approaches for enhancing the love and support in your life in this handbook.

Breast cancer risk:

  • Higher risk of breast cancer among people with inadequate social support (preliminary evidence)
  • No evidence of a higher risk of breast cancer among women experiencing widowhood or divorce in a combined analysis of studies

Risk of cancer as a whole:

  • Higher risk of cancer and cancer mortality among people with lower levels of social support, with some differences between men and women and between white and black Americans (good evidence)
Manage anxiety: good evidence

Find approaches for managing anxiety in this handbook.

Risk of cancer as a whole:

  • Increased risk of cancer among people experiencing anxiety (good evidence)
Manage your body weight: good and modest evidence

Find approaches for managing your body weight in this handbook.

Breast cancer risk:

  • Higher risk of breast cancer or second primary cancer among people with excess body weight (BMI) except regarding young-adult weight (good evidence)
  • Lower risk of breast cancer among women 50 years and older sustaining a loss of more than 4.4 pounds of body weight, with more benefit among women losing more weight (modest evidence)
Manage depression: good evidence

Find approaches for managing depression in this handbook.

Risk of cancer as a whole:

  • Higher risk of cancer among people with depression (good evidence)

Cancer mortality among people without cancer at the start of a study:

  • Higher risk of cancer-specific and all-cause mortality among people with depression (good evidence)
Manage high blood sugar and insulin resistance: good and modest evidence

You can do much on your own, but professional healthcare management may also be necessary.

Find approaches to manage high blood sugar and insulin resistance in this handbook.

Breast cancer risk:

  • Higher risk of breast cancer among women with diabetes, including gestational diabetes (modest evidence)

Risk of cancer as a whole:

  • Higher risk of invasive cancer as a whole among postmenopausal women with diabetes (modest evidence)

Cancer mortality among people without cancer at the start of a study:

  • Higher cancer-specific mortality among people without cancer at baseline with poorer markers of blood sugar balance and insulin sensitivity (good evidence)
Limit alcohol: good evidence

Breast cancer risk:

  • Moderately higher risk of breast cancer among people drinking 35 grams of alcohol per day—about 2 glasses of wine, 2 bottles of beer or 4 ounces of liquor—with increasing risk with even higher amounts (good evidence)

We have not yet published our Limit Alcohol handbook; this statement is from our research so far.

Don’t smoke: strong and modest evidence

Breast cancer risk:

  • 14% higher risk of breast cancer among women who had ever smoked, increasing to 24% higher risk among women who started smoking before age 17 and 35% higher risk among women with a family history of breast cancer (modest evidence)

Cancer as a whole:

  • A clear link between tobacco use and risk of cancer as a whole (good evidence)

We have not yet published our Don’t Smoke handbook; this statement is from our research so far. 

Breastfeeding

Breastfeeding brings many benefits to the mother as well as the infant, including reducing the mother’s risk of breast cancer.16National Cancer Institute. Reproductive History and Cancer Risk. National Institutes of Health. November 9, 2016. Viewed October 5, 2018. Many organizations, including the University of Texas MD Anderson Cancer Center, recommend breastfeeding your infant for at least six months, and longer is better.17Cordeiro B. Breastfeeding lowers your breast cancer risk. The University of Texas MD Anderson Cancer Center. Viewed October 5, 2018.

Aspirin: good evidence

Breast cancer risk:

  • Lower risk of some subtypes of breast cancer—hormone receptor positive tumors, in situ breast tumors—or among postmenopausal women, but not of breast cancer as a whole among people regularly using aspirin (good evidence)
Green tea or EGCG: modest evidence

Breast cancer risk:

  • A slightly lower risk of breast cancer among people drinking green tea (modest and somewhat conflicting evidence)
  • Lower mammographic density (a risk factor for breast cancer) only among women aged 50 to 55, but no evidence of an effect on older healthy postmenopausal women treated with decaffeinated green tea extract capsules (modest evidence)

Cancer as a whole:

  • Insufficient (conflicting) evidence of an effect on risk of cancer as a whole among people drinking green tea, although some evidence shows lower risk of cancer mortality among women but not men
Mediterranean diet: good evidence

Breast cancer risk:

  • Lower risk of breast cancer among people with the highest adherence to a Mediterranean diet, although the effect may vary with the specific types of breast cancer (good evidence)

Risk of cancer as a whole:

  • Lower risk of cancer or cancer mortality among people without cancer at baseline with higher adherence to a Mediterranean diet (good evidence)
Melatonin: modest evidence

Breast cancer risk:

  • Higher risk of breast cancer among people with lower melatonin levels (modest evidence)
Metformin: mixed evidence

Most of metformin’s benefit in cancer risk is seen among people with diabetes or prediabetes.

Breast cancer risk:

  • Insufficient evidence of an effect on risk of breast cancer among people with type 2 diabetes treated with metformin, with possibly lower risk with use for 3 years or longer
  • Fewer grade 3 tumors or triple negative tumors, but higher incidence of ER or PR positive tumors, among people with breast cancer (not specific to diabetes) using metformin at the time of diagnosis (preliminary evidence)
  • Lower Breast Imaging Reporting and Data System (BIRADS) scores and positive pathological biopsy rate among overweight/obese premenopausal women without diabetes treated with metformin (preliminary evidence)

Breast cancer mortality among people without cancer at the start of a study:

  • Lower breast cancer-specific mortality among people without cancer at baseline with diabetes treated with metformin (modest evidence)
  • Slightly lower risk of breast cancer and lower breast cancer-specific mortality among people without cancer at baseline (not specific to diabetes) treated with metformin (modest evidence)

Risk of cancer as a whole:

  • Lower risk of cancer as a whole among people with diabetes treated with metformin (modest evidence)

Cancer mortality among people without cancer at the start of a study:

  • No evidence of an effect on cancer-specific mortality among people at high risk of type 2 diabetes treated with metformin in a very large study
NSAIDs: modest evidence

Breast cancer risk:

  • Lower risk of breast cancer with ibuprofen use (modest evidence)
  • See also higher risk of some types of breast cancer among people using ibuprofen in Safety and precautions ›
Time in nature: modest evidence

Breast cancer risk: 

  • Lower risk of breast cancer among people living in urban areas close to green space (modest evidence)

Cancer mortality among people without cancer at the start of a study:

  • Lower cancer mortality over 8 years among women without cancer at baseline living near higher levels of vegetation (modest evidence)
Vitamin C: mixed evidence

Breast cancer risk:

  • No evidence of an effect on breast cancer risk among people with higher levels of vitamin C intake from diet and/or supplements in a combined analysis of studies
  • Preliminary evidence of a link between low vitamin C levels and breast cancer risk

Cancer as a whole:

  • No evidence of an effect on risk of cancer as a whole among people treated with oral vitamin C in large controlled studies
  • A link between low vitamin C levels and risk of cancer as a whole (modest evidence)
Vitamin D: strong to weak evidence

Breast cancer risk: 

  • Lower mammographic density among premenopausal women at high risk breast of cancer with a low baseline 25(OH)D level treated with vitamin D (weak evidence)
  • Higher risk of breast cancer among people with low 25(OH)D levels, and especially among premenopausal women (good evidence)
  • Slightly lower risk of breast cancer among people with higher vitamin D intake (preliminary evidence)

Risk of cancer as a whole:

  • Lower risk of cancer among healthy adults aged 70 years or older taking vitamin D supplements (modest evidence)
  • Lower risk of cancer among people with higher 25(OH)D levels (weak evidence)

Cancer mortality among people without cancer at the start of a study:

  • Slightly lower cancer mortality among people without cancer at baseline taking vitamin D supplements (strong evidence)
  • Lower cancer mortality among people without cancer at baseline with higher 25(OH)D levels (good evidence)
Vitamin D and calcium together: mixed evidence

See Vitamin D › for the evidence

Breast cancer risk: 

  • No evidence of an effect on risk of invasive breast cancer among postmenopausal women treated with calcium plus vitamin D
  • See also an increase in breast cancer risk among women with higher baseline intake of vitamin D in Safety and precautions ›

Risk of cancer as a whole:

  • Lower risk of cancer as a whole among postmenopausal women treated with vitamin D and calcium (good evidence)

Preliminary or weak evidence for reducing cancer risk

Preliminary evidencesignificant effects in small or poorly designed clinical studies OR conflicting results in adequate studies but a preponderance of evidence of an effect (this is the CancerChoices definition; other researchers and studies may define this differently) means the practice or therapy may be linked to the outcomes described, although substantial uncertainty remains. Weak evidenceone or more case studies, supported by animal evidence OR small treatment effects of limited clinical significance OR studies with no controls OR weak trends of effects (this is the CancerChoices definition; other researchers and studies may define this differently) may mean that the effects are small or that a high degree of uncertainty remains about the links between the practice or therapy and the outcomes described.

Antioxidants Learn moreSee Less
Diindolylmethane (DIM) Learn moreSee Less
Probiotics and prebiotics Learn moreSee Less
Resveratrol Learn moreSee Less
Support groups and interventions Learn moreSee Less
Intravenous vitamin C and PARP inhibitors Learn moreSee Less

Further therapies that may reduce risk of breast cancer

These therapies are reported to reduce risk of breast cancer. We have not fully assessed the evidence, although we provide preliminary reviews as linked.

Agaricales mushrooms

Bisphosphonates, including clodronate and zoledronic acid

Black cohosh

Boswellia

Calcium D-glucarate

Indole-3-carbinol (I3C)

Lutein

Lycopene ›

Screening for cancer in dense breasts

Breast density indicates a higher proportion of fibrous and glandular tissue compared to fatty tissue. Women with dense breasts have a higher risk of breast cancer. The denser the breasts, the higher the risk. Dense tissue can also make tumors more difficult to find in a mammogram, leading to more “missed” cancers during screening.18About Dense Breasts. Centers for Disease Control and Prevention. Viewed May 18, 2024.

A large study in the Netherlands found that supplementing mammograms with magnetic resonance imaging (MRI) for women with very dense breast tissue reduced missed cancers (interval cancers) more than mammography alone.19Bakker MF, de Lange SV et al. Supplemental MRI screening for women with extremely dense breast tissue. New England Journal of Medicine. 2019 Nov 28;381(22):2091-2102.

Helpful links related to dense breasts

How integrative experts approach cancer risk

Clinical practice guidelines

Physical activity is beneficial for the prevention of several types of cancer including breast cancer.

US Preventive Services Task Force

Two guidelines make recommendations regarding reducing risk of cancer.

Breast Cancer: Medication Use to Reduce Risk ›

In their 2019 guideline, the USPSTF recommends that clinicians offer to prescribe risk-reducing medications, such as tamoxifen, raloxifene, or aromatase inhibitors, to women aged 35 or older who are at increased risk for breast cancer and at low risk for adverse medication effects, but do not routinely use risk-reducing medications among women without increased risk of breast cancer

Vitamin, Mineral, and Multivitamin Supplementation to Prevent Cardiovascular Disease and CancerUS Preventive Services Task Force Recommendation Statement ›

Recommends against the use of beta carotene or vitamin E supplements for the prevention of cardiovascular disease or cancer

The current evidence is insufficient to assess the balance of benefits and harms of the use of single- or paired-nutrient supplements (other than beta carotene and vitamin E) for the prevention of cardiovascular disease or cancer. 

Published programs and approaches

Lise Alschuler, ND, FABNO, and Karolyn Gazella

Alschuler LN, Gazella KA. The Definitive Guide to Cancer, 3rd Edition: An Integrative Approach to Prevention, Treatment, and Healing. Berkeley, California: Celestial Arts. 2010.

This book includes an approach for reducing risk of breast cancer.

Lorenzo Cohen, PhD, and Alison Jefferies, MEd

Cohen L, Jefferies A. Anticancer Living: Transform Your Life and Health with the Mix of Six. New York: Viking. 2018.

This book introduces the concept of the Mix of Six, which is identical to six of our 7 Lifestyle Practices ›

Dr. Cohen and Ms. Jefferies explain that while each plays an inde­pendent role, the synergy created by all six factors can radically transform health, delay or prevent many cancers, support conventional treatments, and significantly improve quality of life.

The book describes a risk-reduction program.

Other expert assessments

Recommended actions:

Get to and stay at a healthy weight

Be physically active

Avoid or limit alcohol

Using hormone therapy after menopause can increase your risk of breast cancer.

For women at increased risk of breast cancer:

  • Genetic counseling and testing for breast cancer risk (if it hasn’t been done already)
  • Medicines to lower breast cancer risk
  • Preventive (prophylactic) surgery
  • Close observation to look for early signs of breast cancer

Actions the CDC recommends for reducing risk of breast cancer:

Keep a healthy weight.

Be physically active.

Choose not to drink alcohol, or drink alcohol in moderation.

If you are taking, or have been told to take, hormone replacement therapy or oral contraceptives (birth control pills), ask your doctor about the risks and find out if it is right for you.

Breastfeed your children, if possible.

If you have a family history of breast cancer or inherited changes in your BRCA1 and BRCA2 genes, talk to your doctor about other ways to lower your risk.

Commentary

CancerChoices advisor Ted Schettler, MD, MPH: It takes a village (or a whole country) to reduce the risk of breast cancer

Reducing risk factors for breast cancer “cannot be accomplished by individuals alone. Public health strategies to re-shape the terrain are essential.”20Schettler T. The Ecology of Breast Cancer: The Promise of Prevention and the Hope for Healing. Science and Environmental Health Network and The Collaborative on Health and the Environment. October 2013. Many of these can only partially be addressed by changes in individual behavior. Multi-level public-health and policy interventions at the population level are also necessary in order to re-design system conditions in more favorable ways.

Dr. Schettler synthesizes the research to 2013 and presents practical measures for individuals, healthcare professionals, public health officials, community planners, businesses, schools, governments and farmers to help reduce the burden of this disease at all levels.

Discussing public-health strategies is beyond the scope of this commentary, but we refer readers to Dr. Schettler’s book and to the work of organizations such as the Science and Environmental Health Network › and the Collaborative on Health and the Environment ›

Helpful links

Keep reading about breast cancer

Authors

Laura Pole, MSN, RN, OCNS

Senior Clinical Consultant
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Laura Pole is senior clinical consultant for CancerChoices. Laura is an oncology clinical nurse specialist who has been providing integrative oncology clinical care, navigation, consultation, and education services for over 40 years. She is the co-creator and co-coordinator of the Integrative Oncology Navigation Training at Smith Center for Healing and the Arts in Washington, DC. Laura also manages the “Media Watch Cancer News That You Can Use” listserv for Smith Center/Commonweal. In her role as a palliative care educator and consultant, Laura has served as statewide Respecting Choices Faculty for the Virginia POST (Physician Orders for Scope of Treatment) Collaborative as well as provided statewide professional education on palliative and end-of-life care for the Virginia Association for Hospices and Palliative Care.

For CancerChoices, Laura curates content and research, networks with clinical and organizational partners, brings awareness and education of integrative oncology at professional and patient conferences and programs, and translates research into information relevant to the patient experience as well as clinical practice.

Laura sees her work with CancerChoices as a perfect alignment of all her passions, knowledge and skills in integrative oncology care. She is honored to serve you.

Laura Pole, MSN, RN, OCNS Senior Clinical Consultant

Nancy Hepp, MS

Lead Researcher
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Ms. Hepp is a researcher and communicator who has been writing and editing educational content on varied health topics for more than 20 years. She serves as lead researcher and writer for CancerChoices and also served as the first program manager. Her graduate work in research and cognitive psychology, her master’s degree in instructional design, and her certificate in web design have all guided her in writing and presenting information for a wide variety of audiences and uses. Nancy’s service as faculty development coordinator in the Department of Family Medicine at Wright State University also provided experience in medical research, plus insights into medical education and medical care from the professional’s perspective.

Nancy Hepp, MS Lead Researcher

Gwendolyn Stritter, MD

Physician and CancerChoices advisor
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Dr. Stritter is board-certified in anesthesiology. She was also certified in pain medicine from 1996 to 2016 and served as the director of the Kaiser San Jose Pain Medicine Clinic for 10 years. Wishing to pursue a more patient-centered style of practice, Gwen subsequently trained with Dr. Mark Renneker, honing her medical advocacy skills to help those with life-threatening health problems. Her own high risk for breast cancer led her to focus on that area in particular.

During her 13 years of clinical advocacy practice, she appeared on radio, lectured and wrote many articles on medical advocacy. She also coauthored the chapter on clinical advocacy in the textbook Patient Advocacy for Healthcare Quality: Strategies for Achieving Patient-Centered Care (2007).

As fate would have it, Dr. Stritter was diagnosed with breast cancer in 2013. Although side effects of treatment forced closure of her medical advocacy practice, she continues to enjoy attending several breast cancer conferences every year, learning best integrative oncology practices and mentoring the next generation of breast cancer medical advocates.

Gwendolyn Stritter, MD Physician and CancerChoices advisor

Reviewers

Michael Lerner is co-founder of Commonweal and co-founder of the Commonweal Cancer Help Program, Healing Circles, The New School at Commonweal, and CancerChoices. He has led more than 200 Commonweal Cancer Help Program retreats to date. His book Choices In Healing: Integrating the Best of Conventional and Complementary Approaches to Cancer was the first book on integrative cancer care to be well received by prominent medical journals as well as by the patient and integrative cancer care community.

Michael Lerner Co-Founder

Walter Tsang, MD

Integrative oncologist
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Dr. Walter Tsang is quadruple board-certified in medical oncology, hematology, lifestyle medicine, and internal medicine. In addition to providing cutting-edge treatments for cancer and blood diseases, Dr. Tsang regularly advises his patients on nutrition, physical activity, stress management, and complementary healing methods. He has seen firsthand how this whole-person approach improved his patients’ quality of life and survival.

Outside of his clinical practice, Dr. Tsang teaches integrative oncology at the UCLA Center for East-West Medicine and directs an educational seminar program for cancer survivors in the community. His research interests focus on comparing and integrating the traditional Eastern and modern Western perspectives of cancer care. His fluency in Chinese further allows him to study the enormous integrative medicine literature published in the East that is not easily accessible to the West due to the language barrier.

Dr. Tsang is an active member of the American Society of Clinical Oncology, Society for Integrative Oncology, and American College of Lifestyle Medicine. He currently practices in the Inland Empire region of Southern California.

Walter Tsang, MD Integrative oncologist

Last update: October 16, 2024

Last full literature search: January 2023

CancerChoices provides information about integrative in cancer care, a patient-centered approach combining the best of conventional care, self care and evidence-informed complementary care in an integrated plan cancer care. We review complementaryin cancer care, complementary care involves the use of therapies intended to enhance or add to standard conventional treatments; examples include supplements, mind-body approaches such as yoga or psychosocial therapy, and acupuncture therapies and self-care lifestyle actions and behaviors that may impact cancer outcomes; examples include eating health-promoting foods, limiting alcohol, increasing physical activity, and managing stress practices to help patients and professionals explore and integrate the best combination of conventionalthe cancer care offered by conventionally trained physicians and most hospitals; examples are chemotherapy, surgery, and radiotherapy and complementary therapies and practices for each person.

Our staff have no financial conflicts of interest to declare. We receive no funds from any manufacturers or retailers gaining financial profit by promoting or discouraging therapies mentioned on this site.

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