Off-label, overlooked, or novel cancer approaches (ONCAs) Archives - CancerChoices



Timing of Therapies

Our predecessor site BCCT summarizes the evidence regarding the effects of timing of therapies with cancer.

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Statins

Our predecessor site BCCT summarizes the evidence regarding statins’ effects with cancer.

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Rapamycin (Sirolimus)

By blocking certain functions of the mTOR enzyme, rapamycin reduces cell growth. It therefore may be useful in treating or preventing proliferative diseases, including cancer.

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Propranolol and Other Beta Blockers

Our predecessor site BCCT summarizes the evidence regarding propranolol’s and other beta blockers’ effects with cancer.

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Non-aspirin Nonsteroidal Anti-inflammatory Drugs (NSAIDs)

Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to reduce inflammation, with notable benefits in increasing survival and reducing risk of several types of cancer; expert consensus is that the risks of harm from using these drugs long-term for prevention are greater than the benefits for many people.

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Metformin

Metformin, used to manage diabetes, may lower cancer risk and improve survival, mostly among people with diabetes or high blood sugar.

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Mebendazole or Fenbendazole

Mebendazole, a prescription drug used in humans to treat parasites, and fenbendazole, a treatment for parasites in animals, show promising but so far very preliminary evidence of anticancer effects.

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Low-dose Naltrexone

This prescription drug is used off-label in low doses to treat people with cancer, with notable but very preliminary successes in cases where the cancers were difficult-to-treat or quite advanced.

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Hyperthermia

Many types and varieties of hyperthermia (heat treatment) are used in conventional cancer care, and some additional uses are being explored for improving survival and reducing risk of recurrence.

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Copper Chelation

Copper promotes the formation of blood vessels, including those that supply tumors. Depleting copper can deprive the tumor of its suppliers.

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