Ketogenic diets are high in fat, moderate in protein and low in carbohydrates, with weak to preliminary evidence of anticancer effects, relief of side effects, and benefits on your body terrainthe internal conditions of your body, including nutritional status, fitness, blood sugar balance, hormone balance, inflammation and more.
How do experts use a ketogenic diet?
Experts provide very limited recommendations for a ketogenic diet in treating people with cancer. Learn more about the approaches and meanings of recommendations.
Clinical practice guidelines
A ketogenic diet is not recommended or mentioned in any of the integrative clinical practice guidelines we consult.
Published protocols, programs, and approaches
Ketogenic diet is used only one protocola package of therapies combining and preferably integrating various therapies and practices into a cohesive design for care from an integrative oncologists, drawing from both scientific research and observations from years or even decades of treating people with cancer.
We do not recommend specific integrative protocols or programs but provide information for you to evaluate with your healthcare team.
Neil McKinney, BSc, ND
McKinney N. Naturopathic Oncology, Fourth Edition. Victoria, BC, Canada: Liaison Press. 2020.
This book includes descriptions and uses of many natural and complementary protocols for cancer in general and for specific cancers. It also includes information on integrative support during conventional cancer treatment.
Dr. McKinney uses ketogenic diet for brain/nerve cancer.
Some researchers conclude that insufficient clinical evidence is available to support a recommendation for KD for any single cancer diagnosis or as an adjunct therapy.1Erickson N, Boscheri A, Linke B, Huebner J. Systematic review: isocaloric ketogenic dietary regimes for cancer patients. Medical Oncology. 2017 May;34(5):72. However, others suggest that even with limited human studies, animal studies “show that KD presents a viable option as an adjunct therapy for cancer”2Smyl C. Ketogenic diet and cancer-a perspective. Recent Results in Cancer Research. 2016;207:233-40. and can be a good option to complement other therapies, “depending on the situation and the extent of the disease.”3Branco AF, Ferreira A et al. Ketogenic diets: from cancer to mitochondrial diseases and beyond. European Journal of Clinical Investigation. 2016 Mar;46(3):285-98.
We have not found any credible sources that recommend KD for cancer prevention. Many of the ketogenic diets focus on coconut oil, heavy cream, fatty red meats from conventionally-raised animals—including cured red meats such as bacon and sausage—to achieve high levels of fat. These are not recommended elements of a cancer-protective diet.4Karen Collins, MS, RDN, CDN, FAND, Oncology Dietitian and Nutrition Advisor to the American Institute for Cancer Research. Presentation March 2017: “Culinary Translation in Breast Cancer Care and Survivorship” in Washington, DC.
CancerChoices staff, October 1, 2021: CancerChoices advises that those considering a ketogenic diet consult a clinician who has expertise in prescribing and monitoring ketogenic diets specifically for cancer patients. Additionally, work with a dietitian or qualified clinical nutritionist knowledgeable about ketogenic diets for instructions and ongoing support. Look for “KD-savvy” professionals:
- Consider participating in a clinical trial, favoring those that provide a registered dietitian or qualified clinical nutritionist to provide education, monitoring and ongoing support.
- If considering trying the KD outside of the research setting,
- Find a doctor with expertise in ketogenic diets in cancer (such as a naturopathic or other integrative oncologist) to determine if this is an appropriate therapy for you, set the plan and monitor your response. Favor clinicians who include a registered dietitian or qualified clinical nutritionist to counsel you.
- Work with a registered dietitian or clinical nutritionist experienced in KD counseling for the course of the KD therapy.
Although you can follow a ketogenic diet on your own, the complexity of following the diet and the possibility of side effects make this difficult and potentially dangerous. While web resources and books are available regarding this diet, they are not specifically tailored to people with cancer, nor do they include diet counseling or monitoring.
CancerChoices staff, May 19, 2022: Certain cells in the tumor stroma, along with catabolic cancer cells, release ketones during a process called autophagyconsumption of the body’s own tissue as a metabolic process occurring in fasting, starvation and certain diseases; cellular self-cleansing. These ketones can be taken up by anabolic (proliferative) cancer cells with intact oxidative phosphorylation and utilized to make energy and fuel growth. This raises concern for some clinicians, such as naturopathic oncologist and CancerChoices advisor Lise Alschuler, ND, FABNO. Dr. Alschuler thinks a KD may benefit some cancer patients, but is concerned about using it long-term in someone with active cancer. She thinks there is a role for the KD, but that its usefulness may be limited in duration and may be dependent upon the type and nature of the patient’s tumor. Since not enough research is available yet to determine susceptible cancers, nor to guide dosing and duration of a ketogenic diet, Dr. Alschuler follows tumor markers and imaging to monitor the continued effectiveness of the KD. If tumor growth is detected, she takes the patient off of the KD and transitions them to a different, plant-based diet.5Lise Alschuler, email communications, September 18, 2017, October 24, 25, 26, 2017, and update May 19, 2022.
Keep reading about ketogenic diet
|1||Erickson N, Boscheri A, Linke B, Huebner J. Systematic review: isocaloric ketogenic dietary regimes for cancer patients. Medical Oncology. 2017 May;34(5):72.|
|2||Smyl C. Ketogenic diet and cancer-a perspective. Recent Results in Cancer Research. 2016;207:233-40.|
|3||Branco AF, Ferreira A et al. Ketogenic diets: from cancer to mitochondrial diseases and beyond. European Journal of Clinical Investigation. 2016 Mar;46(3):285-98.|
|4||Karen Collins, MS, RDN, CDN, FAND, Oncology Dietitian and Nutrition Advisor to the American Institute for Cancer Research. Presentation March 2017: “Culinary Translation in Breast Cancer Care and Survivorship” in Washington, DC.|
|5||Lise Alschuler, email communications, September 18, 2017, October 24, 25, 26, 2017, and update May 19, 2022.|