Modified citrus pectin: Are you a health professional? - CancerChoices

Modified citrus pectin is a plant-based dietary supplement with very preliminary evidence of anticancer and antimetastatic effects.

Are you a health professional?

This section does not replicate the other information on this topic but provides additional details or context most relevant to professionals.

Modes of action

Oral consumption of modified citrus pectin controls cancer metastasis by inhibiting the role of the pro-metastatic regulatory protein galectin-3 (Gal3).1Gunning AP, Pin C, Morris VJ. Galectin 3-β-galactobiose interactions. Carbohydrate Polymers. 2013 Jan 30;92(1):529-33.

Preclinical evidence

Notable preclinical evidence is shared here; clinical evidence, and our evaluations, are in How can modified citrus pectin help you? What the research says ›

Treating cancer

Optimizing your body terrain

Managing side effects

  • Increased renal function and attenuated renal fibrosis after cisplatin-induced injury in mice treated with MCP21Li HY, Yang S, Li JC, Feng JX. Galectin 3 inhibition attenuates renal injury progression in cisplatin-induced nephrotoxicity. Bioscience Reports. 2018 Dec 18;38(6):BSR20181803.

Helpful links for professionals

Pectin Professional Monograph ›

Subscription required

Cancer Strategies Journal: Clinical Pearls, Winter 2013
(See Galectin-3 levels and citrus pectin)

Knowledge in Integrative Oncology Website ›
A subscription is required; access is free of charge for members of the Society for Integrative Oncology.

Keep reading about modified citrus pectin


Nancy Hepp, MS

Lead Researcher
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Ms. Hepp is a researcher and communicator who has been writing and editing educational content on varied health topics for more than 20 years. She serves as lead researcher and writer for CancerChoices and also served as the first program manager. Her graduate work in research and cognitive psychology, her master’s degree in instructional design, and her certificate in web design have all guided her in writing and presenting information for a wide variety of audiences and uses. Nancy’s service as faculty development coordinator in the Department of Family Medicine at Wright State University also provided experience in medical research, plus insights into medical education and medical care from the professional’s perspective.

Nancy Hepp, MS Lead Researcher


Andrew Jackson, ND

Research Associate
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Andrew Jackson, ND, serves as a CancerChoices research associate. As a naturopathic physician practicing in Kirkland, Washington, he teaches critical evaluation of the medical literture at Bastyr University in Kenmore, Washington. His great appreciation of scientific inquiry and the scientific process has led him to view research with a critical eye.

Andrew Jackson, ND Research Associate

Last update: December 18, 2023

Last full literature review: April 2023

CancerChoices provides information about integrativein cancer care, a patient-centered approach combining the best of conventional care, self care, and evidence-informed complementary care in an integrated plan cancer care. We review complementaryin cancer care, complementary care involves the use of therapies intended to enhance or add to standard conventional treatments; examples include supplements, mind-body approaches such as yoga or psychosocialtherapy, and acupuncture therapies and self carelifestyle actions and behaviors that may impact cancer outcomes; examples include eating health-promoting foods, limiting alcohol, increasing physical activity, and managing stress practices to help patients and professionals explore and integrate the best combination of conventionalthe cancer care offered by conventionally trained physicians and most hospitals; examples are chemotherapy, surgery, and radiotherapy and complementary therapies and practices for each person.

Our staff have no financial conflicts of interest to declare. We receive no funds from any manufacturers or retailers gaining financial profit by promoting or discouraging therapies mentioned on this site.

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