Turkey Tail Mushroom
Extracts of turkey tail mushroom and its constituent PSK are used with conventional cancer treatment to improve survival and reduce risk of recurrence. The constituent PSP shows some benefit for pain, appetite, and percentage of body fat.
Turkey tail mushroom at a glance
Extracts of turkey tail mushroom and its constituents PSK and PSP are widely available without prescription in capsule, liquid tincture and powdered form. Turkey tail mushroom has been used in traditional Chinese medicine for many years. A formulation called PSK or Krestin™ has been studied and used extensively in Japan for its effects on immune function and also as an adjuvanttreatment applied after initial treatment for cancer, especially to suppress secondary tumor formation cancer treatment.
The greatest benefit for cancer survival and lower risk of recurrence is when turkey tail mushroom or PSK is used in addition to conventional treatment such as chemo/radiotherapy. Use is also linked to better markers of immune function, including after conventional treatment. Some evidence shows less pain and better appetite and levels of body fat with PSP use.
CancerChoices ratings for turkey tail mushroom
We rate turkey tail mushroom on seven attributes, with 0 the lowest rating and 5 the highest. We rate the strength of the evidence supporting the use of turkey tail mushroom for a medical benefit, such as improving treatment outcomes or managing side effects.
See how we evaluate and rate complementary therapies ›
Improving treatment outcomes
See MoreModest evidencesignificant effects in at least three small but well-designed randomized controlled trials (RCTs), or one or more well-designed, mid-sized clinical studies of reasonably good quality (RCTs or observational studies), or several small studies aggregated into a meta-analysis (this is the CancerChoices definition; other researchers and studies may define this differently) of benefit
- Modest evidence of slightly better survival among people with cancer as a whole treated with turkey tail added to conventional treatment
- Modest evidence of better survival among people with colorectal cancer as a whole or colon cancer specifically treated with turkey tail or PSK added to chemotherapy
- Modest evidence of better survival among people with stomach cancer treated with turkey tail or PSK added to chemotherapy
- Preliminary evidence of better survival among people with colorectal cancer treated with PSK alone
- Preliminary evidence of better 10-year overall survival after curative resection among people with colorectal cancer treated with fluoropyramidines and PSK
- Preliminary evidence of better survival among people with breast cancer treated with chemotherapy and adding turkey tail mushroom
- Preliminary evidence of better survival among people with stomach cancer treated with PSK alone
- Preliminary evidence of better survival among people with nasopharyngeal cancer treated with PSK added to radiotherapy
- Preliminary evidence of better survival among people with lung cancer treated with PSK added to chemotherapy
- Preliminary evidence of better survival among people with leukemia treated with PSK added to chemotherapy
- No evidence of an effect on survival among people with rectal cancer treated with tegafur/uracil (UFC) and PSK added to curative surgery in a preliminary study; also see evidence of lower survival and higher risk of recurrence among people with colorectal cancer when combining tegafur/uracil with PSK in Safety and precautions
- No evidence of an effect on survival among people with esophageal cancer treated with turkey tail added to conventional treatment in a combines analysis of 2 studies
- No evidence of better survival among people with liver cancer (hepatocellular carcinoma) and unable to receive standard treatment treated with PSP alone in a preliminary study
See How can turkey tail mushroom help you? What the research says ›
Optimizing your body terrain
See More- Preliminary evidencesignificant effects in small or poorly designed clinical studies OR conflicting results in adequate studies but a preponderance of evidence of an effect (this is the CancerChoices definition; other researchers and studies may define this differently) of higher markers of immune activation among either people rehabilitating from cancer treatment or healthy people treated with turkey tail capsules
See How can turkey tail mushroom help you? What the research says ›
Managing side effects and promoting wellness
See More- Preliminary evidencesignificant effects in small or poorly designed clinical studies OR conflicting results in adequate studies but a preponderance of evidence of an effect (this is the CancerChoices definition; other researchers and studies may define this differently) of better recovery from low lymphocyte, neutrophil and other blood cell counts among people rehabilitating from cancer treatment treated with turkey tail capsules
- Preliminary evidence of better appetite and less pain among people with hepatocellular carcinoma treated with PSP
See How can turkey tail mushroom help you? What the research says ›
Reducing cancer risk
See More- Preliminary evidencesignificant effects in small or poorly designed clinical studies OR conflicting results in adequate studies but a preponderance of evidence of an effect (this is the CancerChoices definition; other researchers and studies may define this differently) of lower markers of cervical and uterine cancer risk among HPV-positive women treated with a C. versicolor-infused vaginal gel
- Preliminary evidence of lower risk of recurrence among people with leukemia treated with PSK
- No evidence of an effect on risk of 5-year recurrence of nasopharyngeal cancer among people treated with PSK added to radiotherapy in a preliminary study
See How can turkey tail mushroom help you? What the research says ›
Use by integrative oncology experts
See More- Widely used by integrative practitioners
- Not mentioned in integrative cancer clinical practice guidelines
Safety
See More- A low rate of side effects, typically mild and temporary, has been reported in early clinical trials
- Moderate caution is needed, especially if you have known bleeding or clotting disorders or are using anticoagulant or antiplatelet agents or immunosuppressants
- Reduced liver function could impact chemotherapy effects
- Supervision by a medical professional is highly recommended
Affordability and access
See More- Widely available without restriction
- Somewhat expensive (between $500 US and $2000 US/year)
Keep reading about turkey tail mushroom
Authors
Ms. Hepp is a researcher and communicator who has been writing and editing educational content on varied health topics for more than 20 years. She serves as lead researcher and writer for CancerChoices and also served as the first program manager. Her graduate work in research and cognitive psychology, her master’s degree in instructional design, and her certificate in web design have all guided her in writing and presenting information for a wide variety of audiences and uses. Nancy’s service as faculty development coordinator in the Department of Family Medicine at Wright State University also provided experience in medical research, plus insights into medical education and medical care from the professional’s perspective.
Andrew Jackson, ND, serves as a CancerChoices research associate. As a naturopathic physician practicing in Kirkland, Washington, he teaches critical evaluation of the medical literture at Bastyr University in Kenmore, Washington. His great appreciation of scientific inquiry and the scientific process has led him to view research with a critical eye.
Laura Pole is senior clinical consultant for CancerChoices. Laura is an oncology clinical nurse specialist who has been providing integrative oncology clinical care, navigation, consultation, and education services for over 40 years. She is the co-creator and co-coordinator of the Integrative Oncology Navigation Training at Smith Center for Healing and the Arts in Washington, DC. Laura also manages the “Media Watch Cancer News That You Can Use” listserv for Smith Center/Commonweal. In her role as a palliative care educator and consultant, Laura has served as statewide Respecting Choices Faculty for the Virginia POST (Physician Orders for Scope of Treatment) Collaborative as well as provided statewide professional education on palliative and end-of-life care for the Virginia Association for Hospices and Palliative Care.
For CancerChoices, Laura curates content and research, networks with clinical and organizational partners, brings awareness and education of integrative oncology at professional and patient conferences and programs, and translates research into information relevant to the patient experience as well as clinical practice.
Laura sees her work with CancerChoices as a perfect alignment of all her passions, knowledge and skills in integrative oncology care. She is honored to serve you.
Last update: June 21, 2024
Last full literature review: October 2021
CancerChoices provides information about integrative in cancer care, a patient-centered approach combining the best of conventional care, self care and evidence-informed complementary care in an integrated plan cancer care. We review complementaryin cancer care, complementary care involves the use of therapies intended to enhance or add to standard conventional treatments; examples include supplements, mind-body approaches such as yoga or psychosocial therapy, and acupuncture therapies and self-care lifestyle actions and behaviors that may impact cancer outcomes; examples include eating health-promoting foods, limiting alcohol, increasing physical activity, and managing stress practices to help patients and professionals explore and integrate the best combination of conventionalthe cancer care offered by conventionally trained physicians and most hospitals; examples are chemotherapy, surgery, and radiotherapy and complementary therapies and practices for each person.
Our staff have no financial conflicts of interest to declare. We receive no funds from any manufacturers or retailers gaining financial profit by promoting or discouraging therapies mentioned on this site.
Learn more