The Gonzalez Protocol™ uses freeze-dried pork pancreas, supplements, an individualized diet, and coffee enemas to alter cancer metabolism and inhibit growth.

Gonzalez Protocol™ at a glance

The Gonzalez Protocol™ includes several approaches with the goal of altering cancer metabolism:1PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Gonzalez Regimen (PDQ™): Patient Version. 2015 Sep 4. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002–. Viewed August 26, 2022. 

  • Freeze-dried pork pancreas rich in naturally occurring pancreatic enzymes and enzyme precursors as the main anticancer component of the protocol
  • A large number (more than 100 per day) of nutritional supplements
  • An individualized diet of mainly organic foods
  • Coffee enemas twice a day 

This protocol combines the work of Nicholas Gonzalez, MD; Linda Isaacs, MD; and William Kelley, DDS. While this protocol has some similarities to the theories and practice of Max Gerson, MD, it differs substantially in supplementation amounts and dietary recommendations.2PDQ Integrative, Alternative, and Complementary Therapies Editorial Board. Gonzalez Regimen (PDQ™): Patient Version. 2015 Sep 4. In: PDQ Cancer Information Summaries [Internet]. Bethesda (MD): National Cancer Institute (US); 2002–. Viewed August 26, 2022. See Gerson Regimen › 

Very few published studies have investigated outcomes among people with cancer treated with the Gonzalez Protocol™. Small studies have shown promising effects on survival. A larger controlled trial found worse outcomes compared to chemotherapy, although published critiques of that study question whether the people purported to be following the Gonzalez Protocol™ were actually doing so.

CancerChoices ratings for the Gonzalez Protocol™

We rate the Gonzalez Protocol™ on seven attributes, with 0 the lowest rating and 5 the highest. We rate the strength of the evidence supporting the use of the Gonzalez Protocol™ for a medical benefit, such as improving treatment outcomes or managing side effects.

See how we evaluate and rate complementary therapies ›


Improving treatment outcomes

See More

Optimizing your body terrain

See More

Managing side effects and promoting wellness

See More

Reducing cancer risk

See More

Use by integrative oncology experts

See More


See More

Affordability and access

See More

Keep reading about the Gonzalez Protocol™


Nancy Hepp, MS

Lead Researcher
View profile

Ms. Hepp is a researcher and communicator who has been writing and editing educational content on varied health topics for more than 20 years. She serves as lead researcher and writer for CancerChoices and also served as the first program manager. Her graduate work in research and cognitive psychology, her master’s degree in instructional design, and her certificate in web design have all guided her in writing and presenting information for a wide variety of audiences and uses. Nancy’s service as faculty development coordinator in the Department of Family Medicine at Wright State University also provided experience in medical research, plus insights into medical education and medical care from the professional’s perspective.

Nancy Hepp, MS Lead Researcher


Laura Pole, MSN, RN, OCNS

Senior Clinical Consultant
View profile

Laura Pole is senior clinical consultant for CancerChoices. Laura is an oncology clinical nurse specialist who has been providing integrative oncology clinical care, navigation, consultation, and education services for over 40 years. She is the co-creator and co-coordinator of the Integrative Oncology Navigation Training at Smith Center for Healing and the Arts in Washington, DC. Laura also manages the “Media Watch Cancer News That You Can Use” listserv for Smith Center/Commonweal. In her role as a palliative care educator and consultant, Laura has served as statewide Respecting Choices Faculty for the Virginia POST (Physician Orders for Scope of Treatment) Collaborative as well as provided statewide professional education on palliative and end-of-life care for the Virginia Association for Hospices and Palliative Care.

For CancerChoices, Laura curates content and research, networks with clinical and organizational partners, brings awareness and education of integrative oncology at professional and patient conferences and programs, and translates research into information relevant to the patient experience as well as clinical practice.

Laura sees her work with CancerChoices as a perfect alignment of all her passions, knowledge and skills in integrative oncology care. She is honored to serve you.

Laura Pole, MSN, RN, OCNS Senior Clinical Consultant

Last update: December 11, 2023

Last full literature review: August 2022

CancerChoices provides information about integrativein cancer care, a patient-centered approach combining the best of conventional care, self care and evidence-informed complementary care in an integrated plan cancer care. We review complementaryin cancer care, complementary care involves the use of therapies intended to enhance or add to standard conventional treatments; examples include supplements, mind-body approaches such as yoga or psychosocial therapy, and acupuncture therapies and self-care lifestyle actions and behaviors that may impact cancer outcomes; examples include eating health-promoting foods, limiting alcohol, increasing physical activity, and managing stress practices to help patients and professionals explore and integrate the best combination of conventionalthe cancer care offered by conventionally trained physicians and most hospitals; examples are chemotherapy, surgery, and radiotherapy and complementary therapies and practices for each person.

Our staff have no financial conflicts of interest to declare. We receive no funds from any manufacturers or retailers gaining financial profit by promoting or discouraging therapies mentioned on this site.

Learn more