During breast cancer treatment
At this time, you’ll likely want to focus on allowing your cancer treatments to be as effective as possible while also keeping side effects under control.
Top practices and therapies we have reviewed for improving cancer outcomes during treatment
These practices and therapies have at least modest evidence for the medical benefits listed. We add to this list as we complete new reviews of practices and therapies.
On this page
How integrative experts approach care during treatment
Clinical practice guidelines
Specific guidelines for managing symptoms and side effects are listed in handbooks for each side effect. See Managing side effects and improving quality of life › below.
Combined moderate-intensity aerobic and resistance exercise performed two to three times per week for at least 12 weeks results in improvements in health-related quality of life both during and after treatment.
The benefit of combined aerobic plus resistance training programs appears more potent than programs consisting of only aerobic or resistance training
Moderate-intensity aerobic training, resistance training or combined aerobic plus resistance training performed three times weekly for 8 to 12 weeks can significantly improve self-reported physical function.
Supervised exercise appears to be more effective than unsupervised or home-based interventions, although unsupervised programs may be effective in older cancer survivors.
It is recommended that, if available, zoledronic acid (4 mg intravenously every 6 months) or clodronate (1,600 mg/d orally) be considered as adjuvant therapy for postmenopausal patients with breast cancer who are deemed candidates for adjuvant systemic therapy. Data for adjuvant denosumab look promising but are currently insufficient to make any recommendation.
This 2018 guideline provides recommendations for the use of self-care practices and complementary therapies for managing symptoms and side effects among people with breast cancer. Specific recommendations are listed in handbooks for each side effect (see below).
Published programs and approaches
Lise Alschuler, ND, FABNO, and Karolyn Gazella
Alschuler LN, Gazella KA. The Definitive Guide to Cancer, 3rd Edition: An Integrative Approach to Prevention, Treatment, and Healing. Berkeley, California: Celestial Arts. 2010.
Lise Alschuler, ND, FABNO, and Karolyn Gazella list five key body pathways to target to make your body inhospitable to cancer. Three of those pathways most relevant to preventing and managing surgical complications are the immune system, insulin resistance and inflammation.
- Chapter 8, Immune system (including stress management)
- Chapter 9, Inflammation
- Chapter 11, Insulin resistance
Alschuler and Gazella also devote a portion of chapters 6 and 7 to integrative approaches to preparing for, mitigating side effects from, and enhancing outcomes of cancer surgery.
Keith Block, MD
Block KI. Life over Cancer: The Block Center Program for Integrative Cancer Care. New York: Bantam Dell. 2009.
Keith Block, MD, advises patients on heart-damaging medications to take 200 mg or even considerably more of CoQ10 per day.1Block KI. Life over Cancer: The Block Center Program for Integrative Cancer Care. New York: Bantam Dell. 2009. p. 25. Many heart patients are also on statins. Block says, “Because statins deplete coenzyme Q10 from your muscle cells, particularly your heart, I advise patients on statins to take at least 30 mg of coQ10 per day.“2Block KI. Life over Cancer: The Block Center Program for Integrative Cancer Care. New York: Bantam Dell. 2009. p. 522.
Raymond Chang, MD, FACP
Chang R. Beyond the Magic Bullet: The Anti-Cancer Cocktail. New York: Square One Publishers. 2012.
Dr. Chang describes a case study of a patient with breast cancer.
Neil McKinney, BSc, ND
McKinney N. Naturopathic Oncology, Fourth Edition. Victoria, BC, Canada: Liaison Press. 2020.
This book includes descriptions and uses of many natural and complementary protocols for cancer in general and for specific cancers. It also includes information on integrative support during conventional cancer treatment.
This book includes a protocol for breast cancer.
Gurdev Parmar, ND, FABNO, and Tina Kaczor, ND, FABNO
Parmar G, Kaczor T. Textbook of Naturopathic Oncology: A Desktop Guide of Integrative Cancer Care. 1st edition. Medicatrix Holdings Ltd. 2020.
This book provides information on the treatment of 24 cancers, plus the most effective treatments of the most common symptoms affecting cancer patients while they undergo chemotherapy, radiotherapy, or surgery.
Traditional medicine approaches
Traditional Chinese medicine (TCM) › uses botanical and animal products, trace elements, diet, and exercise in addition to acupuncture/acupressure.
Traditional Korean medicine has treatment approaches for breast cancer.3Bae K, Kim E, Choi JJ, Kim MK, Yoo HS. The effectiveness of anticancer traditional Korean medicine treatment on the survival in patients with lung, breast, gastric, colorectal, hepatic, uterine, or ovarian cancer: a prospective cohort study protocol. Medicine (Baltimore). 2018 Oct;97(41):e12444.
Examples of integrative approaches
A number of integrative oncology care programs and clinics employ complementary approaches to enhance conventional treatment and/or minimize side effects. Three programs have published studies of their integrative approaches in caring for those with advanced breast cancer. We provide a description of their research, not as endorsements of their programs, but as examples of different integrative approaches to advanced breast cancer care.
Canadian/US Integrative Oncology Study (CUSIOS) study: a naturopathic oncology approach
See the Canadian/US Integrative Oncology Study (CUSIOS) study ›
CancerChoices advisor Leanna Standish, ND, is a Fellow of the American Board of Naturopathic Oncology (FABNO) and works within the research institute of the prestigious naturopathic school Bastyr University. Dr. Standish has been leading research studies looking at integrative therapies that naturopathic oncologists provide, as well as the costs and outcomes of that care.
In one study published in 2017, the Bastyr Integrative Oncology Research Clinic (BIORC), in collaboration with Fred Hutchinson Cancer Research Center, followed 324 women of all stages of breast cancer who received integrative oncology care from board-certified naturopathic oncologists in the Seattle area. The most common integrative therapies prescribed:
- Trametes versicolor (turkey tail mushroom)
- Mind-body therapies
- Acupuncture
- Injectable therapy (mistletoe, vitamin B complex, intravenous vitamin C, intravenous artesunate, and intravenous nutrition and hydration)
The costs ranged from $1594 per year for early stage breast cancer up to $6200 per year for stage 4 breast cancer patients. About 20% of that cost was out-of-pocket, with the remainder paid for by insurance or written off by the university. As the researchers point out, “regardless of the stage of breast cancer, integrative [naturopathic] oncology care is low-cost relative to conventional oncology costs. Standard cancer treatments may cost as much as $10,000 to $40,000 per month.”4Standish LJ, Dowd F et al. Breast cancer integrative oncology care and its costs. Integrative Cancer Therapies. 2017 Mar;16(1):85-95. The extra cost of adding complementary therapies to conventional care may be outweighed by the benefits to patients: better quality of life, symptom management and in some cases improved response to conventional treatment.
Since opening in 2009, BIORC has enrolled 704 patients in a separate prospective outcomes study treating breast, lung, colon, pancreatic, brain and skin cancers. One-third are patients with stage 4 cancer. During the study, the natural products used have been intravenous (IV) high-dose vitamin C, IV artesunate, oral curcumin, green tea and Trametes versicolor (turkey tail mushroom). Dr. Standish shared with us: “Our median overall survival was excellent compared to other published phase III clinical trials.”5Leanna Standish, ND. Email communication, September 29, 2018.
However, a study published in 2021 found that women with breast cancer who received naturopathic oncology care in addition to conventional carethe cancer care offered by conventionally trained physicians and most hospitals; examples are chemotherapy, surgery, and radiotherapy showed worse disease-free or overall survival compared to women who received conventional care only. Part of this difference may have been due to a lower likelihood of using anti-estrogen therapy among women receiving naturopathic care, but this did not fully explain the difference in outcomes.6Standish LJ, Sweet E et al. Recurrence of breast cancer after primary treatment: a matched comparison study of disease-free survival in women who do and do not receive adjunctive naturopathic oncology care. Integrative Cancer Therapies. 2021 Jan-Dec;20:15347354211058404.
Bastyr breast cancer study supplements
No one “Bastyr protocol” exists, as researchers continue to investigate and refine approaches. Supplements used in one Bastyr protocol for breast cancer:7McKinney N. Naturopathic Oncology, 3rd Edition. Victoria, BC, Canada: Liaison Press. 2016.
- Curcumin ›
- Bromelain
- Quercetin ›
- Low-dose naltrexone ›
Naturopathic oncology care › is complementary rather than alternative to conventional care, with complementary therapies used in conjunction with conventional treatments. Naturopathic oncologists are oriented to deliver integrative oncology care in tandem with their conventional oncology colleagues.
UPMC Breast Cancer Integrative Care and Wellness Program
The UPMC Breast Cancer Integrative Care and Wellness Program offers a range of wellness-based and holistic health care both in-house and through referrals to providers in the area. The cancer care team works with integrative medicine experts to look beyond treating breast cancer itself and treat the whole person. The team checks in with patients throughout their treatment, asking especially about how patients are feeling and helping them manage any new concerns.
The UPMC care team includes experts in conventional care specialties.
Cancer surgery
Medical cancer treatments
Radiation
Ear, nose, and throat care
Neuro-oncology
Gynecologic cancer care
Palliative care
Mental health
Integrative offering may include approaches such as these:
Acupuncture
Aromatherapy
Art therapy
Massage
Meditation/mindfulness/hypnosis
Music/sound therapy
Nutrition counseling
Pet therapy
Spiritual counseling
Yoga
Commentary: conventional treatment interactions with drugs and natural products
Tamoxifen interactions
From CancerChoices advisor Jen Green, ND, FABNO, September 1, 2020: Arimidex generally has lower risk of drug interactions as compared to tamoxifen because it is metabolized by p glycoproteins and not CYP pathways in the liver. Tamoxifen, on the other hand, carries greater drug-drug and herb-drug interaction risks because it is extensively metabolized by the CYP2D6 pathway. Tamoxifen shouldn’t be combined with Paxil/paroxetine,8Kelly CM, Juurlink DN et al. Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study. BMJ. 2010;340:c693. Prozac/fluoxetine,9Desmarais JE, Looper KJ. Interactions between tamoxifen and antidepressants via cytochrome P450 2D6. Journal of Clinical Psychiatry. 2009;70(12):1688-1697. Benadryl/diphenhydramine or Tagamet/cimetidine.10National Cancer Institute. Hormone Therapy for Breast Cancer. National Institutes of Health. February 14, 2017. Viewed September 2, 2020.
Out of caution, it should also not be combined with these natural substances:
- DIM 300mg11Thomson CA, Chow HHS et al. A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast Cancer Research and Treatment. 2017;165(1):97-107.
- 3.6g or more of curcumin (7 capsules daily)12Hussaarts KGAM, Hurkmans DP et al. Impact of curcumin (with or without piperine) on the pharmacokinetics of tamoxifen. Cancers (Basel). 2019;11(3):403. (see more below)
- Goldenseal
- St. John’s wort
- Grapefruit
Tamoxifen and curcumin
CancerChoices advisors Gwen Stritter, MD, and Jen Green, ND, FABNO, May 9, 2019: Impact of curcumin on tamoxifen effectiveness
Many are aware that tamoxifen is what we call a pro-drug. A pro-drug is ineffective until specific enzymes in your body activate it. Tamoxifen is metabolized to endoxifen, the effective drug that prevents ER+ breast cancer patients from relapse.
An enzyme called CYP2D6 is responsible for the magic that changes tamoxifen to endoxifen. The activity of this enzyme varies from individual to individual. Part of the variance is due to genetics—some people are born with hyperactive CYP2D6; others have an enzyme that is very sluggish. Many medications—antidepressants like fluoxetine (Prozac), paroxetine (Paxil) and citalopram (Celexa) amongst a host of others—as well as assorted foods and dietary supplements can either activate or slow down CYP2D6.
When this information first started causing a stir in the breast cancer world roughly 10 years ago, researchers hypothesized that taking tamoxifen with a CYP2D6 inhibitor would cause a increase in breast cancer relapse. As it turned out, further clinical research did not bolster this theory,13Mayer SE, Weiss NS et al. CYP2D6-inhibiting medication use and inherited CYP2D6 variation in relation to adverse breast cancer outcomes after tamoxifen therapy. Cancer Causes Control. 2019 Jan;30(1):103-112. leading to a new one: genetics, drugs and dietary intake have complex interactions with the body’s enzyme system. They activate some enzymes and inhibit others. This results in a variable net effect on the concentration of important drugs. In a 2016 study, the cause of low endoxifen levels could not be identified over 50% of the time.14Fox P, Balleine RL et al. Dose escalation of tamoxifen in patients with low endoxifen level: evidence for therapeutic drug monitoring-the TADE study. Clinical Cancer Research. 2016 Jul 1;22(13):3164-71.
Because such a complex system is difficult to study, researchers turned away from looking at just CYP2D6 and are focusing on the endoxifen level itself (ignoring the middleman). In one study, researchers in the Netherlands gave tamoxifen with or without curcumin 1200 mg three times a day. The group taking tamoxifen combined with curcumin had about an 8% decrease in endoxifen levels. If the curcumin was compounded with piperine (often done to substantially improve curcumin absorption), endoxifen levels were further decreased by 12%.15Hussaarts KGAM, Hurkmans DP et al. Impact of curcumin (with or without piperine) on the pharmacokinetics of tamoxifen. Cancers (Basel). 2019 Mar 22;11(3). pii: E403.
Although an 8 to 12% reduction doesn’t seem like much, if your genetics and/or dietary habits result in levels of endoxifen just barely in the effective range, the addition of curcumin, and especially with piperidine, could tip the scales in favor of breast cancer growth. The authors of this paper conclude: “co-treatment with curcumin could lower endoxifen concentrations below the threshold for efficacy (potentially 20 to 40% of the patients).”
Do keep in mind that this was a very small study, only 16 patients. However, these results are in line with previous lab and animal research so should not be discounted. On the other hand, curcumin supplementation has documented beneficial effects: decreased depression,16Sanmukhani J, Satodia V et al. Efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. Phytotherapy Research. 2014 Apr;28(4):579-85. anti-inflammatory effects17Panahi Y, Saadat A, Beiraghdar F, Sahebkar A. Adjuvant therapy with bioavailability-boosted curcuminoids suppresses systemic inflammation and improves quality of life in patients with solid tumors: a randomized double-blind placebo-controlled trial. Phytotherapy Research. 2014 Oct;28(10):1461-7. and lowered cholesterol,18Qin S, Huang L et al. Efficacy and safety of turmeric and curcumin in lowering blood lipid levels in patients with cardiovascular risk factors: a meta-analysis of randomized controlled trials. Nutrition Journal. 2017 Oct 11;16(1):68. to name a few.
The bottom line: if you are taking curcumin with tamoxifen, ask your integrative practitioner if s/he could substitute another supplement. If not, then request to have your endoxifen levels checked, both before and a month after starting curcumin. Quest Diagnostics, a very reputable lab, offers a “tamoxifen and metabolites” blood test.
Herbal and botanical therapies in general
CancerChoices advisor Debu Tripathy, MD, writes that “herbal and botanical agents have significant potential as bioactive agents that can affect cellular pathways involved in breast cancer, but may also cause side effects and drug interactions. . . Caution should be exercised when used with other treatments.”19Tripathy D. Chapter 21: Integrative Medicine and Breast Cancer in Abrams DI, Weil AT. Integrative Oncology, 2nd Edition. New York, NY: Oxford University Press. 2014.
Commentary: medicinal mushrooms in breast cancer care
CancerChoices advisor Lise Alschuler, ND, FABNO, August 9, 2018: There are instances when I use specific mushrooms, for instance: Coriolus (or Trametes) versicolor (turkey tail) for breast cancer, Agaricus blazeii for ovarian cancer and chaga mushroom for melanoma. However, it is a very valuable and reasonable strategy to use a blend that includes mushrooms, each of which is standardized to its polysaccharides and beta-glucans. The key is to use a hot water extract of the fruiting bodies or a full-spectrum extract (includes mycelium) that clearly identifies on its label the quantity of mushroom extract.
Some blends that I often recommend:
Per capsule:
- Trametes versicolor (turkey tail) (40% polysaccharides, 40% beta-glucans)—100mg
- Grifola frondosa (maitake) 40% polysaccharides, 30% beta-glucans—100mg
- Ganoderma lucidum (reishi), 40% polysaccharides, 15% beta-glucans—100mg
- Lentinula edodes (shiitake), 409% polysaccharides, 40% beta-glucans—100mg
I would recommend between 2-3 capsules twice daily.
When recommending single mushrooms, it is important to know how much beta-glucan is in each serving so that I can titrate my dose accordingly. For instance, I often use Grifola frondosa (maitake) mushroom to increase white blood cell counts. One product I use contains:
Per 6 tablets:
- Maitake (Grifola frondosa) Fruiting body powder – 600mg
- Maitake fruiting body extract, standardized to contain 30% D-fraction—240mg (so 72mg D-fraction beta glucan)
- Vitamin C 120mg (supports bioactivity)
Costs permitting, in most clinical studies, the daily dose of mushroom extracts that is correlated with improved survival (especially in breast, colorectal, gastric cancers) is 3000mg/day.
Mushrooms do pack a punch! From a meta-analysis on Coriolus versicolor mushroom extracts in patients diagnosed with cancer:20Eliza WL, Fai CK, Chung LP. Efficacy of Yun Zhi (Coriolus versicolor) on survival in cancer patients: systematic review and meta-analysis. Recent Patents on Inflammation & Allergy Drug Discovery. 2012 Jan;6(1):78-87.
- Over all cancers, there was a 9% absolute reduction in 5-year mortality (one additional patient alive for every 11 patients treated).
- Effects were more evident for breast, gastric or colorectal cancer versus esophageal or nasopharyngeal.
CancerChoices advisor Brian Bouch, MD, reviews the different therapies for breast cancer care.
Play videoImproving treatment outcomes
You can be active in improving your response to cancer treatment. Self-carelifestyle actions and behaviors that may impact cancer outcomes; examples include eating health-promoting foods, limiting alcohol, increasing physical activity, and managing stress practices and complementaryin cancer care, complementary care involves the use of therapies intended to enhance or add to standard conventional treatments; examples include supplements, mind-body approaches such as yoga or psychosocial therapy, and acupuncture therapies can improve your treatment outcomes—promoting survival, reducing metastasis, reducing tumor growth, and otherwise improving your response to conventional treatment. Please also review the Safety and precautions page within the linked reviews for guidance on safe use. We recommend supervision from a medical professional trained in the use of complementary therapies.
While wise use of complementary therapies may improve treatment outcomes, no complementary or alternativein cancer care, alternative practices or therapies such as diets or acupuncture are used instead of conventional treatments such as chemotherapy, surgery, or radiotherapy; if a therapy is used with conventional treatments, it is considered complementary and not alternative therapy is a suitable stand-alone treatment for breast cancer.
Adherence to treatment is not a direct measure of anticancer action, but we include it here because any factor that increases adherence to anticancer treatment contributes to the direct action and potential success of that treatment.
These practices and therapies add to those listed in At any time during your breast cancer experience ›
Details of the evidence supporting the statements are in the reviews available through the image links.
Strong, good, or modest evidence of benefit for treatment outcomes
Strong evidenceconsistent, significant effects in several large (or at least one very large) well designed clinical studies or at least two meta-analyses of clinical studies of moderate or better quality (or one large meta-analysis) finding similar results (this is the CancerChoices definition; other researchers and studies may define this differently) indicates confidence that the practice or therapy has an effect as noted. Good evidencesignificant effects in one large or several mid-sized and well-designed clinical studies (randomized controlled trials (RCTs) with an appropriate placebo or other strong comparison control or observational studies that control for confounds) (this is the CancerChoices definition; other researchers and studies may define this differently) indicates that the practice or therapy is linked to the outcomes described with reasonable certainty. Modest evidencesignificant effects in at least three small but well-designed randomized controlled trials (RCTs), or one or more well-designed, mid-sized clinical studies of reasonably good quality (RCTs or observational studies), or several small studies aggregated into a meta-analysis (this is the CancerChoices definition; other researchers and studies may define this differently) means the practice or therapy may be linked to the outcomes described, but with a lower degree of certainty.
The evidence for these effects is described in the reviews available through the image links.
Moving More: modest evidence
Find strategies for moving more in this handbook.
Cancer as a whole:
- Possibly better chemotherapy completion rates, but no evidence of improved response rate or survival among people with cancer participating in aerobic exercise during chemotherapy (modest evidence)
Sharing Love and Support: good evidence
Find strategies for enhancing the love and support in your life in this handbook.
Specific to breast cancer:
- Greater adherence to breast cancer treatment among people with higher levels of social support (good evidence)
Manage your body weight: modest evidence
Find strategies for managing your body weight in this handbook.
Specific to breast cancer:
- Worse prognosis and survival among people who are obese or those who either gained or lost more than 10% of their body weight, but mostly among people diagnosed with breast cancer after menopause (modest evidence)
Cancer as a whole:
- A less effective response to chemotherapy among obese people (modest evidence)
Also see the impacts of excess body weight on surgery outcomes › below
Astragalus: modest evidence
Specific to breast cancer:
- Better tumor response to chemotherapy among people with breast cancer treated with herbal mixtures containing astragalus (modest evidence)
- Higher treatment completion rates among people with breast cancer and capecitabine-associated hand-foot syndrome treated with an herbal mixture containing astragalus (preliminary evidence)
Melatonin: strong evidence
Cancer as a whole:
- Better survival, tumor response, and remission among people with solid tumors treated with melatonin, mostly when combined with conventional treatments (strong evidence)
Mistletoe: mixed evidence
Specific to breast cancer:
- No evidence of an effect on relapse or metastasis among people with breast cancer treated with mistletoe during chemotherapy in a preliminary study
Cancer as a whole:
- Better survival among people with cancer as a whole treated with Iscador (modest evidence)
- Lower rates of discontinuation of standard cancer treatment (preliminary evidence)
Reishi mushroom: mixed evidence
Cancer as a whole:
- A better response to chemo/radiotherapy among people with cancer as a whole treated with reishi mushrooms (modest evidence)
- No evidence of an effect on long‐term survival among people treated only with reishi in a combined analysis of studies
Turkey tail mushroom: modest and preliminary evidence
Specific to breast cancer:
- Better survival among people with breast cancer treated with chemotherapy and adding turkey tail mushroom (preliminary evidence)
Cancer as a whole:
- Slightly better survival among people with cancer as a whole treated with turkey tail added to conventional treatment (modest evidence)
Preliminary or weak evidence of benefit for treatment outcomes
Preliminary evidencesignificant effects in small or poorly designed clinical studies OR conflicting results in adequate studies but a preponderance of evidence of an effect (this is the CancerChoices definition; other researchers and studies may define this differently) means the practice or therapy may be linked to the outcomes described, although substantial uncertainty remains. Weak evidenceone or more case studies, supported by animal evidence OR small treatment effects of limited clinical significance OR studies with no controls OR weak trends of effects (this is the CancerChoices definition; other researchers and studies may define this differently) may mean that the effects are small or that a high degree of uncertainty remains about the links between the practice or therapy and the outcomes described.
Insufficient evidence or no evidence of an effect for treatment outcomes
Cimetidine and other H2 blockers ›
Specific to breast cancer:
- No evidence of an effect on tumor cell proliferation among people with breast cancer treated with cimetidine before surgery in a small study
Specific to breast cancer:
- No evidence of an effect on breast density among women with breast cancer prescribed tamoxifen treated with DIM
Guided imagery combined with relaxation techniques ›
Specific to breast cancer:
- No evidence of an effect on proliferation or response to radiotherapy or chemotherapy among people with breast cancer participating in relaxation and visualization therapy in small trials
Cancer as a whole:
- Insufficient evidence of anticancer effects overall
Non-aspirin nonsteroidal anti-inflammatory drugs (NSAIDs) ›
Specific to breast cancer:
- No evidence of an effect on treatment among people with postmenopausal breast cancer treated with celecoxib, either alone or when combined with exemestane in 2 studies
Further therapies that may provide benefit for treatment outcomes
These therapies are reported to have anticancer effects. We have not fully assessed the evidence, although we provide preliminary reviews as linked.
L-theanine
Improving breast cancer surgery outcomes
Find strategies for improving outcomes across cancer types in a separate handbook. Information specific to breast cancer is listed below.
Reducing risk of complications and infection after surgery
- Before leaving the hospital, be sure you (and anyone who will be assisting you at home) fully understand and follow all wound care instructions carefully. Call your physician immediately if you show any signs of infection—an increase of redness, swelling, pain, or discharge from your wound.
- Avoid contact with soil for two or more weeks after surgery.
- Avoid procedures that might introduce infection to the breast, such as nipple piercing or a tattoo.
- In the weeks following your surgery, if you need a medical procedure that may introduce bacteria to the body, check with your surgeon about using antibiotics to prevent infection.
Infection response
Despite best efforts, people can sometimes still get an infection after breast surgery. Fortunately, it is uncommon for a mild infection to cause a significant worsening of outcomes. But knowing what to do (and what not to do) will help prevent a mild infection from becoming a serious one.
If you do get an infection:
- Report symptoms of infection immediately to your surgeon and begin treatment promptly. If antibiotics are prescribed, take as directed.
- Eat well to maintain a healthy nutritional state. Consider consulting a board-certified oncology dietician for specific dietary recommendations.
- If antibiotics are prescribed, eat well and follow other practices to restore a healthy microorganism balance.
- Consider consulting an integrative oncology specialist about additional measures to clear infection, help wound healing, control inflammation, and minimize tissue fibrosis (scarring) from surgical wounds and/or from radiation therapy.
Reducing the risk of chronic pain after mastectomy or breast reconstruction
From medical advocate, breast cancer survivor, and CancerChoices advisor Gwendolyn Stritter, MD
About 15 to 20% of patients have moderate to severe chronic pain after breast cancer surgery.21Meretoja TJ, Andersen KG et al. Clinical prediction model and tool for assessing risk of persistent pain after breast cancer surgery. Journal of Clinical Oncology. 2017 May 20;35(15):1660-1667. Regional anesthesia (also known as nerve blocks) has been shown to reduce the risk of persistent pain after breast surgery.22Levene JL, Weinstein EJ et al. Local anesthetics and regional anesthesia versus conventional analgesia for preventing persistent postoperative pain in adults and children: a Cochrane systematic review and meta-analysis update. Journal of Clinical Anesthesia. 2019 Aug;55:116-127; Kairaluoma PM, Bachmann MS, Rosenberg PH, Pere PJ. Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery. Anesthesia and Analgesia. 2006 Sep;103(3):703-8. Thoracic paravertebral blocks and PECS blocks are the two types of regional anesthesia most widely used.
Performing such nerve blocks before surgical incision allows for “light” general anesthesia (such as primarily using IV propofol instead of inhaled gases). This in turn results in quickly “waking up” from anesthesia without nausea › or prolonged grogginess. Enough evidence shows that regional anesthesia lowers the chance of subsequent relapse and metastasis.23Kim R. Anesthetic technique and cancer recurrence in oncologic surgery: unraveling the puzzle. Cancer Metastasis Review. 2017 Mar;36(1):159-177.
Not all anesthesiologists have the training or experience to do these blocks well. An appointment with the anesthesia team well in advance of surgery will increase the odds of getting these blocks before mastectomy. I had bilateral paravertebral blocks for my double mastectomy and required only oral anti-inflammatory medication for post-op pain control.
Gwen Stritter’s Painless Double Mastectomy
Dr. Stritter’s experience was documented in this video.
Play videoPractices and therapies with good or modest evidence of benefit for improving surgery outcomes
Good evidencesignificant effects in one large or several mid-sized and well-designed clinical studies (randomized controlled trials (RCTs) with an appropriate placebo or other strong comparison control or observational studies that control for confounds) (this is the CancerChoices definition; other researchers and studies may define this differently) indicates that the practice or therapy is linked to the outcomes described with reasonable certainty. Modest evidencesignificant effects in at least three small but well-designed randomized controlled trials (RCTs), or one or more well-designed, mid-sized clinical studies of reasonably good quality (RCTs or observational studies), or several small studies aggregated into a meta-analysis (this is the CancerChoices definition; other researchers and studies may define this differently) means the practice or therapy may be linked to the outcomes described, but with a lower degree of certainty.
The evidence for these effects is described in the reviews available through the image links.
Moving More: good evidence
Find strategies for moving more in this handbook.
Cancer surgery or other types of surgery:
- Shorter hospital stays and substantially fewer complications from cancer surgery or other types of surgery among people participating in exercise training before surgery (good evidence)
Manage your body weight: good and modest evidence
Find strategies to manage your body weight in this handbook.
Cancer as a whole:
- Longer surgery times, higher illness (morbidity) after surgery, higher rates of conversion from laparoscopic to open surgery, and higher risk of infection and other complications related to surgery among people who are obese (good evidence)
- Higher risk of surgical site infection among people who are obese (modest evidence)
NSAIDs: modest evidence
Specific to breast cancer:
- Better survival among people with breast cancer treated with ketorolac around the time of surgery (modest evidence)
Practices and therapies with preliminary or weak evidence of benefit for improving surgery outcomes
Preliminary evidencesignificant effects in small or poorly designed clinical studies OR conflicting results in adequate studies but a preponderance of evidence of an effect (this is the CancerChoices definition; other researchers and studies may define this differently) typically indicates that not much research has been published so far, although the outcomes may be meaningful. Weak evidenceone or more case studies, supported by animal evidence OR small treatment effects of limited clinical significance OR studies with no controls OR weak trends of effects (this is the CancerChoices definition; other researchers and studies may define this differently) may mean that the effects are small or that only very preliminary research has been published.
Further therapies reported to provide benefit for surgery outcomes
Mind-body therapies › including meditation, music therapy, cognitive-behavioral therapy, and hypnosis
Managing side effects and improving quality of life
Self-care practices as well as supplements, mind-body therapiesapproaches that enhance your mind’s capacity to positively affect your body’s function and symptoms. Some interventions focus on calming your mind, improving focus, enhancing decision-making capacity, managing stress, or resolving conflict. Other interventions have a goal of relaxing both your mind and your body., and other complementaryin cancer care, complementary care involves the use of therapies intended to enhance or add to standard conventional treatments; examples include supplements, mind-body approaches such as yoga or psychosocialtherapy, and acupuncture therapies may reduce symptoms and side effects and enhance your quality of life during cancer treatment. In addition, managing side effects may allow you to complete your cancer treatment, allowing for more benefit from conventional treatments.
Practices and therapies listed here have evidence of managing side effects and symptoms or generally improving quality of life during cancer treatment or surgery. Therapies that can help at any phase of your cancer experience are listed in At any time during your breast cancer experience ›
For some symptoms and side effects, we have complete handbooks, as linked below. For other symptoms and side effects, and for quality of life and physical function as a whole, we list here the effects of complementary therapies and practices we’ve reviewed. Details of the evidence supporting the summary statements are in the linked pages.
We report the evidence relating to benefits from using these therapies. Please also review the Safety and precautions page within the linked reviews for guidance on safe use. We recommend supervision from a medical professional trained in the use of complementary therapies.
Quality of life or physical function as a whole
Strong, good, or modest evidence of benefit for quality of life or physical function as a whole
Moving More: strong to modest evidence
Find strategies for moving more in this handbook.
Specific to breast cancer:
- Better fitness, shoulder mobility, strength, and quality of life, and less disability among people with breast cancer participating in exercise during treatment (strong evidence)consistent, significant effects in several large (or at least one very large) well designed clinical studies or at least two meta-analyses of clinical studies of moderate or better quality (or one large meta-analysis) finding similar results (this is the CancerChoices definition; other researchers and studies may define this differently)
Cancer as a whole:
- Better fitness, strength, and quality of life among people participating in exercise during treatment, except not among people with shoulder dysfunction due to treatment for head and neck cancer (good evidence)significant effects in one large or several mid-sized and well-designed clinical studies (randomized controlled trials (RCTs) with an appropriate placebo or other strong comparison control or observational studies that control for confounds) (this is the CancerChoices definition; other researchers and studies may define this differently)
- Less toxicity during chemotherapy among people with cancer participating in exercise (modest evidence)significant effects in at least three small but well-designed randomized controlled trials (RCTs), or one or more well-designed, mid-sized clinical studies of reasonably good quality (RCTs or observational studies), or several small studies aggregated into a meta-analysis (this is the CancerChoices definition; other researchers and studies may define this differently)
Acupuncture: modest evidence
Cancer as a whole:
- Better physical performance and quality of life during conventional treatment among people treated with acupuncture (modest evidence)
Astragalus: good evidence
Cancer as a whole:
- Better quality of life during chemotherapy or radiotherapy among people treated with herbal medicines containing astragalus (good evidence)
Guided imagery: modest and preliminary evidence
Specific to breast cancer:
- More comfort during radiation therapy among women with early stage breast cancer treated with guided imagery (preliminary evidence)significant effects in small or poorly designed clinical studies OR conflicting results in adequate studies but a preponderance of evidence of an effect (this is the CancerChoices definition; other researchers and studies may define this differently)
- Better quality of life during cancer treatment after mastectomy among women participating in mind-body therapies including mental images (preliminary evidence)
- More comfort during radiation therapy among women with early stage breast cancer treated with guided imagery (preliminary evidence)
Cancer as a whole:
- Better quality of life and related measures during chemotherapy among people treated with guided imagery, sometimes with other mind-body therapies (modest evidence)
Melatonin: modest and preliminary evidence
Cancer as a whole:
- Less chemotherapy-related toxicity among people treated with melatonin (modest evidence)
Mistletoe: good and modest evidence
Cancer as a whole:
- Fewer side effects of conventional treatments among people treated with mistletoe (good evidence)
- Better quality of life during chemotherapy among people with cancer as a whole treated with mistletoe (modest evidence)
Reishi mushroom: modest and preliminary evidence
Specific to breast cancer:
- Better emotional function during endocrine therapy among people with breast cancer treated with reishi mushrooms (preliminary evidence)
Cancer as a whole:
- Better quality of life during chemotherapy or endocrine therapy among people treated with reishi mushroom (modest evidence)
Tai chi or qigong: modest evidence
Cancer as a whole:
- Better quality of life during conventional cancer treatment among people practicing tai chi (modest evidence)
Preliminary or weak evidence of benefit for quality of life or physical function as a whole
No evidence or insufficient evidence of benefit for quality of life or physical function as a whole
Cancer as a whole:
- No evidence of an effect on recovery time or return to normal physical activities among people undergoing major laparoscopic procedures treated with acupressure devices in a preliminary study
Further therapies reported to provide benefit for quality of life or physical function
Anxiety
This handbook includes a description of practices and therapies that can help you manage anxiety.
Blood-related side effects
Good or modest evidence of benefit for blood-related side effects
Melatonin: modest evidence
Cancer as a whole:
- Less severe reductions in blood cell counts during chemo/radiotherapy among people treated with 20 mg oral melatonin, but no evidence of an effect with 40 mg oral melatonin (modest evidence)
Mistletoe: modest evidence
Cancer as a whole:
- Fewer reductions in white blood cells from chemotherapy, surgery, and/or radiotherapy among people treated with mistletoe (modest evidence)
Moxibustion: modest and preliminary evidence
Cancer as a whole:
- Better white blood cell counts during or after conventional cancer treatment among people treated with moxibustion (modest evidence)
- Higher serum hemoglobin during or after chemo/radiotherapy among people treated with moxibustion (modest evidence)
- Higher platelets during chemo/radiotherapy among people with cancer treated with moxibustion compared to no treatment, but no further benefit when added to conventional treatment (preliminary evidence)
Reishi mushroom: modest evidence
Cancer as a whole:
- Better levels of blood components during chemotherapy among people treated with reishi mushrooms (modest evidence)
Turmeric and curcumin: modest evidence
Cancer as a whole:
- Less neutropenia during chemotherapy (modest evidence)
See cautions about blood-related side effects of use in Safety and precautions ›
Preliminary or weak evidence of benefit for blood-related side effects
Further therapies reported to provide benefit for blood-related symptoms
Inositol hexaphosphate
Body composition or cachexia
Good or modest evidence of benefit for body composition or cachexia
Moving More: strong and good evidence
This handbook includes strategies for moving more.
Cancer as a whole:
- Increased lean body mass and less body fat or obesity during neoadjuvant or adjuvanttreatment applied after initial treatment for cancer, especially to suppress secondary tumor formation chemotherapy, radiotherapy, or hormone therapy, including androgen deprivation therapy, among people participating in exercise (good evidence)
Further therapies reported to provide benefit for body composition and cachexia
Bone and joint symptoms
Good or modest evidence of benefit for bone and joint symptoms
Acupuncture: good evidence
Specific to breast cancer:
- Less stiffness but no evidence of an effect on quality of life during hormone therapy among people with breast cancer treated with acupuncture (good evidence)
Preliminary or weak evidence of benefit for bone and joint symptoms
Further therapies reported to provide benefit for bone and joint symptoms
Black cohosh
Isothiocyanates
Cardiovascular side effects
Also see Taking care of your heart below.
Good evidence of benefit for cardiovascular side effects
Manage your body weight: good evidence
Not specific to cancer:
- Higher risks of cardiovascular complications after surgery among people with excess body weight (good evidence)
Preliminary or weak evidence of benefit for cardiovascular side effects
Further therapies reported to provide benefit for cardiovascular side effects
Acetyl-L-carnitine
Allicin
Coenzyme Q10
Indole-3-carbinol (I3C)
Changes in appetite
Modest evidence of benefit for changes in appetite
Vitamin C: intravenous use: modest evidence
Less loss of appetite during standard cancer treatment among women with breast cancer treated with intravenous vitamin C (modest evidence)
Preliminary or weak evidence of benefit for changes in appetite
See our handbook on the Beyond Conventional Cancer Therapies website: Changes in appetite ›
Cognitive difficulties
Preliminary or weak evidence of benefit for cognitive difficulties
Depression
This handbook includes a description of practices and therapies that can help you manage depression.
Fatigue
This handbook includes a description of practices and therapies that can help you manage fatigue.
Gastrointestinal symptoms
This handbook includes a description of practices and therapies that can help you manage gastrointestinal symptoms including constipation, diarrhea, nausea and vomiting, and heartburn.
Hair loss
Preliminary or weak evidence of benefit for hair loss
Hot flashes
This handbook includes a description of practices and therapies that can help you manage hot flashes.
Kidney side effects
Preliminary or weak evidence of benefit for kidney side effects
Lymphedema
Preliminary or weak evidence of benefit for lymphedema
Further therapies reported to provide benefit for lymphedema
Selenium
Neuropathy and other neurological symptoms
This handbook includes a description of practices and therapies that can help you manage neuropathy and other neurological symptoms such as changes in sensation, lack of coordination, ringing in ears, and more.
Oral symptoms
Preliminary or weak evidence of benefit for oral symptoms
Further therapies reported to provide benefit for oral symptoms
Aloe vera
L-glutamine
Rose geranium in sesame oil nasal spray
Pain
This handbook includes a description of practices and therapies that can help you manage pain.
Sepsis
Good evidence of benefit for sepsis
Vitamin C: intravenous use: good evidence
Not specific to cancer:
- Lower mortality and better SOFA scores, which are the sum of respiratory status, liver function, renal function, coagulation function, circulatory status, and nervous system score, among people with sepsis treated with IV vitamin C (good evidence)
Sexual difficulties
Preliminary evidence of benefit for sexual difficulties
See our handbook on the Beyond Conventional Cancer Therapies website: Sexual difficulties ›
Skin and tissue symptoms
Preliminary or weak evidence of benefit for skin and tissue symptoms
Further therapies reported to provide benefit for skin and tissue damage
Grape seed extract
L-glutamine
Sleep disruption
This handbook includes a description of practices and therapies that can help you improve your sleep quality.
Wound healing
Insufficient (conflicting) evidence of benefit for wound healing
Cancer as a whole:
- Insufficient (conflicting) results of better healing of acute wounds among people with cancer
Taking care of your heart: heart health and breast cancer
With contributions from CancerChoices advisor Jen Green, ND, FABNO
Caring for your heart is an important part of your wellness plan. The relationship between breast cancer and heart health may work both ways:
- After a breast cancer diagnosis, 35% of deaths are related not to breast cancer, but to cardiovascular disease.24Lemanne D, Maizes V. Advising women undergoing treatment for breast cancer: a narrative review. Journal of Alternative and Complementary Medicine. 2018 Sep/Oct;24(9-10):902-909.
- A heart attack raises the risk of death from recurrence.25Koelwyn GJ, Newman AAC et al. Myocardial infarction accelerates breast cancer via innate immune reprogramming. Nature Medicine. 2020;26(9):1452-1458.
As part of your treatment, you may be given toxic drugs and/or radiation therapy to kill cancer cells. The normal cells in and around your heart can also be killed, resulting in cardiac toxicity. Besides cell death, cancer treatment can lead to cardiomyopathy, heart failure, acute coronary syndromes, and other heart-related conditions.26Florescu M, Cinteza M, Vinereanu D. Chemotherapy-induced cardiotoxicity. Maedica (Bucur). 2013 Mar;8(1):59-67.
People with breast cancer who are undergoing chemotherapy such as anthracylines (including Adriamycin/doxorubicin), targeted agents such as Herceptin/trastuzumab, and radiation therapy to the chest are at risk for heart damage. Risk is even higher for those receiving anthracyclines plus Herceptin, or anthracyclines plus chest radiation.
From a conventional treatment standpoint, preventing heart problems from cancer treatment involves a baseline test of heart function, monitoring those at risk for problems, and adjusting drug dosage and/or frequency or even changing to a less cardiotoxic drug. Radiation oncology is becoming more and more adept at targeting the cancerous tissue and shielding the heart and lungs.
Your doctor should monitor you for early signs of heart disease and manage risk factors—cholesterol levels, blood pressure and lifestyle.27Koelwyn GJ, Newman AAC et al. Myocardial infarction accelerates breast cancer via innate immune reprogramming. Nature Medicine. 2020;26(9):1452-1458. If your doctor hasn’t mentioned cardiovascular care yet, consider bringing it up.
Early treatment of heart problems is more likely to prevent serious damage. The first step is to get a baseline test of heart function (usually an echocardiogram, or ECG), and repeat testing during cancer treatment if you are at risk for heart problems.28Zamorano J-L, Saltijeral A, Perez de Isla L. Cardiac monitoring for patients under chemotherapy. E-Journal of Cardiology Practice. 2008 Nov 25;7(11).
An echocardiogram should be taken periodically during treatment—every three months during treatment with Herceptin/trastuzumab, according to guidelines from the American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging and European Society for Medical Oncology.29Tan C, Denlinger C. Cardiovascular toxicity in cancer survivors: current guidelines and future directions. American College of Cardiology. June 29, 2018. Viewed April 2, 2019. An “echo” takes pictures of the heart and measures the strength of the heart/ejection fraction. Ejection fraction over 55% is normal, a mildly weak heart is at 45 to 55%, a moderately weak heart is 30 to 45%, and below 30% is considered severely weakened.
After treatment with doxorubicin, repeat testing is recommended at 4 and 10 years after treatment.30Curigliano G, Cardinale D et al. Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy: ESMO Clinical Practice Guidelines. Annals of Oncology. 2012 Oct;23 Suppl 7:vii155-66. Survivors of childhood cancer should have an echocardiogram every one to five years throughout their lives31Denlinger CS, Sanft T et al. Survivorship, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network. 2018 Oct;16(10):1216-1247. and during late-stage pregnancy.32Children’s Oncology Group. Heart Health: Health LinkHealthy living after treatment of childhood cancer. October 2013. Viewed April 2, 2019.
“Heart healthy” lifestyle choices
You can do much more than having diagnostic tests periodically. You can be actively involved in reducing your risk of heart damage and cardiovascular disease.
Cancer survivors can follow these approaches to reduce risks:
- 7 Lifestyle Practices
- Healthy lifestyle
- Ask your doctor about the supplements and approaches mentioned in this section.
Lifestyle practices are the first steps to get your cardiovascular system in the best shape possible, before treatment if possible but also as part of your survivorship plan for health. “Heart healthy” lifestyle choices include the 7 Lifestyle Practices of eating well, moving more, managing stress and sharing love and support.
Exercise during treatment—as much as you can tolerate—can be especially beneficial: “Our findings strongly support that tailored exercise training during adjuvanttreatment applied after initial treatment for cancer, especially to suppress secondary tumor formation breast cancer treatment may counteract a decline in cardiovascular function, and in particular among those receiving chemotherapy.”33Thune I, Husøy A et al. Cardiovascular function and the effect of exercise training during adjuvant breast cancer treatment. Results from The EBBA-II trial. Presentation at the San Antonio Breast Cancer Symposium (SABCS) 2018. December 7, 2018.
Be sure to consult your doctor before starting an exercise program, particularly if you already have heart issues or other problems such as neuropathy that may require adjusting a fitness plan. In this case, a cardiac or cancer rehab program may guide you in choosing safe exercise and movement therapies.
Other foundations for protecting your heart:
- Don’t smoke
- Manage your body weight
- Avoid drugs that stress the heart:
- Cocaine
- Diet pills
- Ephedra/ma huang
- Performance-enhancing drugs
- Caffeinated energy drinks34Gray B, Ingles J, Medi C, Driscoll T, Semsarian C. Cardiovascular effects of energy drinks in familial long QT syndrome: a randomized cross-over study. International Journal of Cardiology. 2017 Mar 15;231:150-154.
Natural therapies protecting your heart during Adriamycin/doxorubicin treatment
Please connect with an integrative oncology professional or naturopathic physician for specific guidance.
Cancer survivors who took milk thistle during doxorubicin treatment had better heart function compared to placebo. The researchers concluded that silymarin “can be recommended as adjuvant drug in patients with ALL under doxorubicin therapy.”35Hagag AA, El Shehaby WA, El-Abasy AI, Mabrouk MM. Protective role of silymarin in early doxorubicin induced cardiac dysfunction in children with acute lymphoblastic leukemia. Infectious Disorders Drug Targets. 2018 Aug 3. An earlier trial showed that milk thistle is safe to combine with chemotherapy.36Ladas EJ, Kroll DJ et al. A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer. 2010 Jan 15;116(2):506-13.
Coenzyme Q10 (CoQ10)
CoQ10 use preserved heart function during doxorubicin treatment37Iarussi D, Auricchio U et al. Protective effect of coenzyme Q10 on anthracyclines cardiotoxicity: control study in children with acute lymphoblastic leukemia and non-Hodgkin lymphoma. Molecular Aspects of Medicine. 1994;15 Suppl:s207-12. and radiation treatment.38Takimoto M, Sakurai T et al. [Protective effect of CoQ 10 administration on cardial toxicity in FAC therapy]. [Article in Japanese]. Gan To Kagaku Ryoho. 1982 Jan;9(1):116-21. Researchers hypothesize that CoQ10 prevents doxorubicin from binding to heart muscle cells.39Okuma K, Furuta I, Ota K. [Protective effect of coenzyme Q10 in cardiotoxicity induced by adriamycin]. [Article in Japanese]. Gan To Kagaku Ryoho. 1984 Mar;11(3):502-8.
Before taking CoQ10, consult your doctor. Because CoQ10 is an antioxidant, it may theoretically interfere with some chemotherapy drugs—such as anthracyclines and cyclophosphamide—or radiation therapy. “Recent in-vitro [cell] studies, however, have shown that CoQ10 does not affect the antineoplastic properties of doxorubicin.”40The Summaries. Coenzyme Q10. CAM-Cancer. June 21, 2016. Viewed October 8, 2018.
L-carnitine
Many people who have low carnitine from chemotherapy will have weakness in large muscle groups, which can make your legs feel like Jello when walking up stairs. L-carnitine is established for improving heart function following a heart attack. Use of L-carnitine after a heart attack was associated with a 27% lower risk of death and 65% lower risk of irregular heart rate.41DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O’Keefe JH. L-carnitine in the secondary prevention of cardiovascular disease: systematic review and meta-analysis. Mayo Clinic Proceedings. 2013 Jun;88(6):544-51.
Among people with cancer, L-carnitine use during doxorubicin treatment improved signs of heart muscle toxicity. Young cancer survivors who received doxorubicin have lower plasma carnitine levels than controls, so L-carnitine has been suggested as a way to prevent heart damage.42Waldner R, Laschan C et al. Effects of doxorubicin-containing chemotherapy and a combination with L-carnitine on oxidative metabolism in patients with non-Hodgkin lymphoma. Journal of Cancer Research and Clinical Oncology. 2006 Feb;132(2):121-8.
Ginkgo
People who took the ginkgo extract Gingold during doxorubicin treatment had fewer abnormal echocardiograms.43Yi SY, Nan KJ, Chen SJ. [Effect of extract of Ginkgo biloba on doxorubicin-associated cardiotoxicity in patients with breast cancer]. [Article in Chinese]. Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Jan;28(1):68-70. Because ginkgo does not affect how most medicines are metabolized, it appears to be safe to combine with chemotherapy,44Markowitz JS, Donovan JL, Lindsay DeVane C, Sipkes L, Chavin KD. Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers. Journal of Clinical Psychopharmacology. 2003 Dec;23(6):576-81. tamoxifen, anastrozole, or letrozole.45Vardy J, Dhillon HM et al. Investigation of herb-drug interactions with ginkgo biloba in women receiving hormonal treatment for early breast cancer. Springerplus. 2013 Mar 22;2(1):126.
Ginkgo use in addition to aspirin (either 325 mg46Gardner CD, Zehnder JL, Rigby AJ, Nicholus JR, Farquhar JW. Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: a randomized clinical trial. Blood Coagulation and Fibrinolysis. 2007 Dec;18(8):787-93. or 500 mg47Wolf HR. Does Ginkgo biloba special extract EGb 761 provide additional effects on coagulation and bleeding when added to acetylsalicylic acid 500 mg daily? Drugs in R&D. 2006;7(3):163-72.) did not increase risk of bleeding.
Arginine
People who took arginine during doxorubicin treatment had less shortness of breath, palpitations, and fewer changes in electrocardiograms.48Skrypnyk I, Maslova G, Lymanets T, Gusachenko I. L-arginine is an effective medication for prevention of endothelial dysfunction, a predictor of anthracycline cardiotoxicity in patients with acute leukemia. Experimental Oncology. 2017 Dec;39(4):308-311.
Women who took iodine during epirubicin chemotherapy for breast cancer had significantly lower levels of heart distress enzymes (creatine kinase-MB) than those taking a placebo.49Moreno-Vega A, Vega-Riveroll L et al. Adjuvant effect of molecular iodine in conventional chemotherapy for breast cancer. randomized pilot study. Nutrients. 2019 Jul 17;11(7). pii: E1623.
Helpful link
This printer-friendly brochure from our previous site (BCCT), published in collaboration with partners, describes approaches you can take to protect your heart.
Protecting Your Heart during Anthracycline/Adriamycin/Doxorubicin Chemotherapy ›
Natural therapies protecting your heart during treatment with Herceptin/trastuzumab, Perjeta/pertuzumab or Kadcyla/trastuzumab emtansine
Studies of these herbs or natural supplements show improvements in heart strength/ejection fraction. These may be useful if your heart strength is reduced from treatment with Herceptin or Kadcyla. Please connect with an integrative oncology professional or naturopathic physician for specific guidance.
Hawthorn berry/crataegus
Hawthorne berry improved heart strength/ejection fraction and symptoms among people with congestive heart failure.50Pittler MH, Schmidt K, Ernst E. Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. American Journal of Medicine. 2003 Jun 1;114(8):665-74.
L-carnitine
L-carnitine improved heart strength/ejection fraction and symptoms among people with congestive heart failure.51Song X, Qu H et al. Efficacy and safety of L-carnitine treatment for chronic heart failure: a meta-analysis of randomized controlled trials. BioMed Research International. 2017;2017:6274854.
Taurine
Taurine has improved heart function and signs of congestive heart failure among people with heart conditions.52Azuma J, Sawamura A et al. Therapeutic effect of taurine in congestive heart failure: a double-blind crossover trial. Clinical Cardiology. 1985 May;8(5):276-82; Ahmadian M, Dabidi Roshan V, Ashourpore E. Taurine supplementation improves functional capacity, myocardial oxygen consumption, and electrical activity in heart failure. Journal of Dietary Supplements. 2017 Jul 4;14(4):422-432.
Combination of taurine, CoQ10 and L-carnitine
People with heart conditions who took 3 g taurine, 3 g carnitine and 150 mg CoQ10 had better heart function.53Jeejeebhoy F, Keith M, et al. Nutritional supplementation with MyoVive repletes essential cardiac myocyte nutrients and reduces left ventricular size in patients with left ventricular dysfunction. American Heart Journal. 2002 Jun;143(6):1092-100.
Weak evidence of better heart function, better 6-minute walking distance and better scores on quality of life among people with chronic heart failure treated with astragalus
Modest evidence of better cardiovascular symptoms among people with cardiovascular conditions treated with berberine
Safety note: Dr. Barbara MacDonald recommends against taking berberine during taxol treatment.54MacDonald B. The Breast Cancer Companion: A Complementary Care Manual: Third Edition. 2016.
Magnesium
People with severe congestive heart failure who took magnesium had better symptoms and survival.55Stepura OB, Martynow AI. Magnesium orotate in severe congestive heart failure (MACH). International Journal of Cardiology. 2009 May 1;134(1):145-7.
Managing pain after breast cancer surgery
Many options are available for managing pain after surgery.
Opioids
According to one national report,562018 Exposing a Silent Gateway to Persistent Opioid Use – A Choices Matter Status Report. Pacira BioSciences, Inc. Viewed September 10, 2019. 18% of opioid addicts or persistent users got their first opioid prescription after surgery. Evidence also shows that use may increase your risk of cancer recurrence.57Aich A, Gupta P, Gupta K. Could perioperative opioid use increase the risk of cancer progression and metastases? International Anesthesiology Clinics. 2016 Fall;54(4):e1-e16. These are both good reasons to carefully consider whether use is necessary.
Fortunately, some hospitals are now discharging even their post-mastectomy patients without any opioids at all and, despite this, are achieving better pain control than with standard treatment that includes opioids. Maimonides Medical Center in Brooklyn, New York, is on the forefront of this movement, as discussed in their 2019 paper, Mastectomy is no longer an indication for postoperative narcotic.58Rojas KE, Fortes TA et al. Mastectomy is no longer an indication for postoperative narcotic. Americal Journal of Surgery. 2019 Jul 18. pii: S0002-9610(19)30177-1. Many other hospitals are instituting their own opioid-avoiding protocols. Dr. Stritter strongly recommends that you ask your surgeon at the pre-op visit whether their hospital has a post-mastectomy opioid-sparing ERAS (Enhanced Recovery After Surgery) protocol. While we are in the throes of an opioid epidemic, it makes a lot of sense to minimize unnecessary opioid prescriptions.
In addition to pain control, some retrospective studies suggest that a single intraoperative dose of NSAIDs such as ketorolac may even reduce the risk of breast cancer recurrence.59Retsky M, Demicheli R et al. Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review. Current Medicinal Chemistry. 2013;20(33):4163-76. But a single dose may not be enough.
Dr. Stritter, once interested in the idea of using such a protocol for breast cancer surgery, has come to a different conclusion. “The initial reports60Retsky M, Demicheli R et al. Reduction of breast cancer relapses with perioperative non-steroidal anti-inflammatory drugs: new findings and a review. Current Medicinal Chemistry. 2013;20(33):4163-76. were based on retrospective, observational studies that had no control group.” Dr. Stritter’s confidence in those reports evaporated when Forget published her updated report—“a definitive prospective, randomized trial—at the 2018 San Antonio symposium that showed no effect of a single dose of intraoperative ketorolac on early recurrences.”61Forget P, Bouche G et al. Intraoperative ketorolac in high-risk breast cancer patients with and without inflammation. A prospective, randomized, placebo-controlled clinical trial. Cancer Research 2019;79(4 Suppl):Abstract # P1-20-01. Dr. Stritter thinks it doesn’t make physiological sense that a single dose of ketorolac would reduce the chance of recurrence or metastasis. “The healing breast would have the epigenetic, genetic and proteonomic changes of wound healing—a well-documented pro-oncogenic environment—for several weeks until the incision has healed.” That is why after her bilateral mastectomy, Dr Stritter used anti-inflammatories (and no opioids) during her entire post-operative period, not only for pain relief but in hopes of creating an anti-oncogenic tumor microenvionment.
A 2018 review of anesthetic interventions in breast cancer concluded that “based on the available evidence, an ideal anesthetic in this patient population would involve a combination of TIVA (propofol), regional anesthesia (paravertebral block), non opioid sedatives (clonidine or dexmedetomidine), and COX-2 inhibition (ketorolac).”62Eden C, Esses G, Katz D, DeMaria S Jr. Effects of anesthetic interventions on breast cancer behavior, cancer-related patient outcomes, and postoperative recovery. Surgical Oncology. 2018 Jun;27(2):266-274.
The overall surgery experience may differ by age. Preliminary evidence shows more severe depressive and anxiety symptoms and sleep disturbance, and subsequent worse pain-related functioning in younger women compared to older women.63Wilson J, Colebaugh C, Flowers K, Schreiber KL. Different than your mother’s pain: postsurgical pain modulation by psychosocial factors among younger and older breast cancer patients. Journal of Pain. 2022;23(5)Supplement:40.
Breast cancer surgery and opioid dependence
Even though addiction is not common overall among opioid users with cancer, a study of women undergoing mastectomy with reconstructive surgery as part of cancer treatment investigated use of opioids and sedative-hypnotic drugs.
These women are at particularly high risk of becoming dependent on opioids following surgery. Among people who had not used an opioid before surgery, about 17% of those filling an opioid prescription after surgery became a chronic user in the year following surgery. More than 17% of women who filled a prescription for a sedative-hypnotic drug became chronic users of these drugs. The researchers recommend women work closely with the prescribing provider to attempt to minimize risk of dependence.64The ASCO Post Staff. SABCS 2020: Opioid and sedative-hypnotic use after mastectomy with reconstructive surgery. December 23, 2020. Viewed February 5, 2021; Cogan JC, Raghunathan RR et al. Persistent controlled substance use following mastectomy with reconstruction surgery. Publication Number: GS3-0. 2020 San Antonio Breast Cancer Symposium®. Viewed February 5, 2021.
Recovering from Surgery: Non-drug therapies that can reduce inflammation, pain, and opioid use related to cancer surgery are evaluated in this handbook.
This handbook describes an integrative approach to managing pain.
Dr. Stritter’s approach
Dr. Gwen Stritter, MD, medical advocate and board-certified anesthesiologist, had bilateral mastectomy for breast cancer. She followed this approach, without opioids, to achieve good pain control and speedy recovery after her 2014 surgery:
- Before incision: IV ketorolac, 30 mg; bilateral paravertebral blocks
- During surgery: no opioids; no nitrous oxide; lots of IV propofol
- After surgery:
- Ibuprofen 800 mg every 8 hours around the clock
- Omeprazole 20 mg twice a day to avoid the gastrointestinal issues
- After about five or six days, started to get a lot of edema from the ibuprofen so stopped ibuprofen and omeprazole; switched to boswellia and curcumin
Dr. Stritter’s “pole dance” following her double mastectomy
Play videoHelpful links
Lucius K, Trukova K. Integrative therapies and cardiovascular disease in the breast cancer population: a review, part 1. Integrative Medicine (Encinitas). 2015 Aug;14(4):22-9.
Kim E, Andersen MR, Standish LJ. Comparison of health-related quality of life between adjuvant breast cancer treatment groups. Oncology Nursing Forum. 2019 Jan 13;46(1):59-70.
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References